20. Symposium “Infektion und Immunabwehr“ Burg Rothenfels 09.03

20. Symposium “Infektion und Immunabwehr“
Burg Rothenfels
09.03. – 11.03.2016
20. Minisymposium „Infektion und Immunabwehr“
Burg Rothenfels, 09. – 11. März 2016
SCIENTIFIC PROGRAM
20. Minisymposium „Infektion und Immunabwehr“
Burg Rothenfels,
9. - 11. März 2016
PROGRAMM
Organisation:
R. Lang, Erlangen
N. Reiling, Borstel
G. van Zandbergen, Langen
Mittwoch, 09.03.2016
14:45
Abfahrt Bus-Shuttle Würzburg Hauptbahnhof (Vorplatz)
15:30 – 16:45
Ankunft, Zimmerverteilung, Kaffee und Gebäck
16:45
Session 1: Pathogen sensing and its consequences
Chair:
Alexander Dalpke and Ger van Zandbergen
Stefan Bauer, Marburg (p. 13)
A Plasmodium falciparum–specific nucleoside
activates TLR8
25‘
Alexander Dabrowski, Berlin (p. 19)
Role of Peptidoglycan Recognition Protein 2
in Streptococcus Pneumoniae Infection
Philipp Georg, Berlin (p. 25)
Human mucosa associated invariant T (MAIT) cells produce
IL-26 and exert direct antibacterial activity
Miriam Krusch, Borstel (p. 34)
Functional validation of MBL in a murine model of
aerogenic M.tuberculosis induction
2
20. Minisymposium „Infektion und Immunabwehr“
Burg Rothenfels, 09. – 11. März 2016
Bernd Lepenies, Hannover (p. 37)
The C-type lectin receptor CLEC12A contributes to cerebral
malaria development
17:58-18:10
Kaffeepause
Moritz Pfeiffer, Berlin (p. 44)
Mechanisms of bacterial RNA-mediated
inflammasome activation in human phagocytes
Anja Schulze, Düsseldorf (p. 49)
Cellular mechanisms of IFNβ induction in MCMV infection
Barbara Killy, Erlangen (p. 31)
miRNAs in cord factor-mediated inhibition of IFNγ-induced
gene expression in murine macrophages
Dagmar Hildebrand, Heidelberg (p. 27)
TLR-APC-mediated tolerance mechanisms and their regulation
through miRNAs
18:58 – 20:00
Abendessen
20:00
Key note lecture: Anca Dorhoi, MPI Infection Biology, Berlin
“Versatile myeloid cells regulate inflammation in
tuberculosis”
ab ca. 21 Uhr
Chill out
Donnerstag, 10.03.2016
8:45 – 10:10
Session 2: Micromilieu and metabolism
Chair:
Anca Dorhoi and Gerhard Krönke
Jonathan Jantsch, Regensburg
Elementary Infection-immunology: Na+ and O2 in myeloid
cell-driven host defense
25‘
Maren Bechberger, Heidelberg (p. 14)
The influence of IL-1beta on the gut microbiome
3
20. Minisymposium „Infektion und Immunabwehr“
Burg Rothenfels, 09. – 11. März 2016
Sandra Förmer, Heidelberg (p. p 23)
T cells under the influence of hypoxia
Dirk Friedrich, Lübeck (p. 24)
HIF-1 alpha promotes the fungicidal activity of human
macrophages during infection with Histoplasma capsulatum
Elena Kostadinova, Berlin (p. 33)
NLRP3 protects alveolar barrier integrity by an
inflammasome-independent increase of epithelial cell adherence
Melanie Nehring, Essen (p. 41)
Enhanced susceptibility to infections in autoimmune type 1
diabetes is associated with dysfunctional dendritic cells
10:10 – 10:25
Kaffeepause
10:25
Session 3: Anti-microbial control and pathogen
countermeasures
Chair:
Katharina Kubatzky and Jonathan Jantsch
Maike Burmeister, Borstel (p. 18)
Acid sphingomyelinase is required for immune control
of Mycobacterium tuberculosis infection
Masa Ivin, Vienna (p. 29)
Type I interferons have a protective role in
Klebsiella pneumoniae pulmonary infection
Valesca Lindenberg, Düsseldorf (p. 38)
Exploring the role of Guanylate binding proteins
in Chlamydia trachomatis infection
Dorinja Zapf, Borstel (p. 56)
The role of virulence-associated ESAT-6 in
Mycobacterium tuberculosis-infected human neutrophils
11:13 – 11:25
Kaffeepause
Markus Kindermann, Erlangen (p. 32)
Analysis of novel reporter mice for ILC fate-mapping in
health and disease
4
20. Minisymposium „Infektion und Immunabwehr“
Burg Rothenfels, 09. – 11. März 2016
Stephan de Oliveira, Langen (p. 43)
Complement Receptor 1 mediated control of Leishmania
infection in inflammatory human macrophages
Valentin Schatz, Regensburg (p. 48)
Myeloid cell-derived HIF-1α is required for cutaneous
control of Leishmania major
Didier Soulat, Erlangen (p. 52)
Biochemical and functional characterization of
two secreted Leishmania major phosphatases
12:13 – 13:15
Mittagessen
anschließend Spaziergang und Kaffee
15:30 – 16:43
Session 4: Regulation by epigenetics and microbiota
Chair:
Stefanie Scheu and Christoph Hölscher
Clarissa Prazeres da Costa, München (p. 45)
25’
Chronic helminth infection during pregnancy epigenetically
reprograms T cell differentiation: A novel concept of helminthinduced transplacental immunomodulation?
Matthias Hauptmann, Borstel (p. 26)
Pulmonary Microbiota: Impact on Lung Morphology,
Respiratory Diseases and Immune Responses
Dennis Nurjadi, Heidelberg (p. 42)
The role of innate and adaptive immune response as
determinants of Staphylococcus aureus carriage
Larissa Faaß, Heidelberg (p. 22)
The role of indoleamine 2,3-dihydrogenase (IDO) in skin
colonization by Staphylococcus aureus
5
20. Minisymposium „Infektion und Immunabwehr“
Burg Rothenfels, 09. – 11. März 2016
Till Strowig, Braunschweig (p. 53)
Distinct requirements for the microbiota in the induction
of anti-bacterial Th17, Th17/22 and Th22 CD4+ T cell
populations in the intestine
16:43 – 17:00
Kaffeepause
17:00 – 17:48
Session 5: Signaling in immune cells and its alteration
during infection
Chair:
Stefanie Flohé and Norbert Reiling
Shafaqat Ali, Düsseldorf (p. 11)
Differential expression of a novel isoform of Dlg2 in IFNβ
producing pDCs
Martin Eberhardt, Erlangen (p. 20)
Gene expression profiling in combination with computational
analysis highlights a druggable regulatory core in macrophages
Madlen Wolff, Erlangen (p. 54)
Reprogramming of murine macrophages by the mycobacterial
cord factor
Katharina Kubatzky, Heidelberg (p. 35)
The Osteoimmunology behind Pasteurella multocida Toxin
Signalling
17:48 – 18:00
Kaffeepause
Johanna Sauer, Lübeck (p. 47)
Impact of the Transcriptional Factor Irf4 on Metabolism in
Activated B cells
Thomas Kufer, Hohenheim (p. 36)
The cofilin phosphatase slingshot homolog 1 (SSH1)
links NOD1 signaling to actin remodelling
Christin Kabus, Berlin (p. 30)
Induction and Function of the stem cell factor c-myc in
Pneumonia caused by Streptococcus pneumoniae and
Legionella pneumophila
6
20. Minisymposium „Infektion und Immunabwehr“
Burg Rothenfels, 09. – 11. März 2016
Hubertus Hochrein, Martinsried (p. 28)
IFN-lambda production of CD8 cDCs in response to DNAviruses, transfected dsDNA or cyclic-di-nucleotides depends on
STING
18:48 – 19:30
Fachgruppenaktivitäten
Ger van Zandbergen, Roland Lang
Vorsitzende der Fachgruppe/des Arbeitskreises
19:30
Key note lecture: Gerhard Krönke, University Hospital
Erlangen
“Enzymatic lipid oxidation as regulatory checkpoint during
inflammation and immunity”
ca. 20:30
Buffet
Freitag, 11.03.2016
8:45 – 09:33
Session 6: Induction and function of T cells in infection
Chair:
Clarissa Prazeres da Costa and Roland Lang
Annemieke Abel, Hamburg (p. 10)
LAG-3 expression on T cells correlates with milder
Symptoms of malaria
Rebecca Bohn, Langen (17)
The induction of LC3-associated phagocytosis in primary human
macrophages suppresses the adaptive immune response
Franziska Muscate, Hamburg (p. 40)
CD160 expression characterises a highly activated and cytotoxic
CD8+ T cell population in experimental malaria
Kristina Ritter, Borstel (p. 46)
Interleukin-23 promotes the induction of protective multifunctional
CD4 T cells after subunit Mycobacterium tuberculosis
vaccination independently of interleukin-17A
09:33 – 09:45
Kaffeepause
7
20. Minisymposium „Infektion und Immunabwehr“
Burg Rothenfels, 09. – 11. März 2016
09:45
Christian Schütz, Langen (p. 50)
A nanoparticle based approach for antigen-specific redirection of
T cells to tumors
Anna Smirnov, Essen (p. 51)
Role of CXCR4 in the appearance of CD11chiMHCII+CD4+ DC
during polymicrobial sepsis
Katharina Arens, Langen (p. 12)
Investigating the role of TNF-alpha in infection using authorized
anti-TNF-alpha monoclonal antibodies
Ana-Belen Erazo, Borstel (p. 21)
Investigation of myeloid-derived suppressor cells during
Plasmodium infection
10:33 – 10:45
Kaffepause
10:45 – 11:58
Session 7: Co-infection
Chair:
Bianca Schneider and Bernd Lepenies
Bianca Schneider, Borstel
Co-infections as potential risk factors to promote active
Mycobacterium tuberculosis infection
25‘
Sonakshi Bhattacharjee, München (p. 15)
Co-infection of H.pylori and S.mansoni: Implications
on immune responses and disease progression
Jannike Blank, Borstel (p. 16)
One Episode of Self-Resolving Plasmodium yoelii Infection
Transiently Exacerbates Chronic Mycobacterium tuberculosis
Infection
Eva Loffredo-Verde, München (p. 39)
Schistosome-induced IFN- suppresses HBV replication and
induces virus-specific T cells
Ling Yao, Berlin (p. 55)
Investigating the Role of Myeloid-Derived Suppressor Cells in
Bacterial Superinfections of Viral Pneumonia
8
20. Minisymposium „Infektion und Immunabwehr“
Burg Rothenfels, 09. – 11. März 2016
11:58
Closing Remarks
12:10
Ende der Tagung
Lunchpaket / Mittagessen
13:00
Abfahrt Bus (pünktlichst!)
9