Alfons Gierl Lehrstuhl für Genetik Emil-Ramann

Alfons Gierl
Lehrstuhl für Genetik
Emil-Ramann-Str. 8
WZW
Technische Universität München
[email protected]
08161-715640
Chapter 1
Genetics?
Modern Genetik Analysis
Griffiths et al
Freemann
Concepts of Genetics
Klug et al.
Pearson International Edition (2009)
Molecular Biology of THE CELL
Alberts et al
Garland Science
Biotechnology
Applying the Genetic Revolution
David P. Clark, Nanette J. Pazdernik
Academic Press
http://www.wzw.tum.de/genetik/
Downloadbereich
Username: genetics
Password: GMendel
Genetics is
the analysis of the basis of heredity
Mendel
Chromosomes
DNA
Genetic Dissection
Biosynthetic pathway
Enzymes
A
B
C
Genes
A
B
C
Mutation
Gene
Function
Genome Projects
Bacteria, Yeast, Drosophila, C. elegans, Human, Arabidopsis
DNA sequence
(whole genome)
bioinformatics
gene function
Reverse Genetics
AGACTTTCCAA....
DNA sequence
(of gene in question)
gene knock out
gene function
Genetics is one basis for gene technology
Transgenic animals, plants and microorganisms
Transgenic mouse
Wild type MET1 antisense
Genetic model systems
Which features qualify an organism?
Genetic model systems
E. coli
Yeast
C.elegans
Drosophila
Zebra Fish
Mouse
Arabidopsis
Maize
low costs
many progeny
many phenotypes
compact genomes