Supervision of Student Theses
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Supervision of Student Theses Diploma thesis 1. G. Oberländer: Experimentelle Untersuchungen zur Befruchtungsphysiologie der männlichen Ratte (Rattus norvegicus) unter Verwendung der Fertilitätshemmers Ornidazol. 1991. Experimental studies on the physiology of fertilisation in the male rat (Rattus norvegicus) under the influence of the antifertility compound ornidazole. 1991. 2. S. Weydert. Vergleichende Untersuchungen zur Spermienreifung bei Cavia aperea und Galea musteloides, zwei Meerschweinchenarten mit unterschiedlingem Paarungssystem. 1998. Comparative studies of sperm maturation in Cava aperea and Galea musteloides, two guinea pig species with different mating systems. 1998. M.D. theses 1. T. Gudermann. Sekretion von myo-Inositol und L-carntine in das Lumen der Cauda epididymidis der Ratte. 1989. Secretion of carnitine and inositol into the lumen of the cauda epididymidis of rat. 1989. 2. A. Burgert. Direktionale Molekültransport durch kultivierte Nebenhodenepithel der Ratte. 1993. Directional molecular transport across cultured epididymal epithelial cells. 1993. 3. D. Wenker. Zellkultur des Nebenhodenepithels der maturen Ratte auf einer permeablen Filtermembran. 1993. Culture of adult rat epididymal epithelial cells on a permeable membrane. 1993. 4. R. Meyer. Anzüchtung immaturer Rattennebenhodenepithelzellen in einer statischen Monolayerkultur auf permeablen Trägern. 1994. Secretory activity of rat epididymal epithelial cells in static monolayer culture on permeable supports. 1994. 5. K. Mennicke. Vergleich der Morphologie und Motilität von humanen Spermien bei verschiedene Gefriermethoden mit computerassistierte Spermienanalyse. 1994. Comparison of the morphology and motility of human sperm after different freezing protocols with computer-aided sperm analysis. 1994. 6. U. Oberdieck. Einfluss von Karenzzeit und Ejakulatfrequenz auf die Zusammensetzung des Ejakulats. 1996. Influence of abstinence time and ejaculation frequency on the composition of the ejaculate. 1996. 7. M. Wulfhorst. Modifikation der Aufthaumethode. 1997. Modification of thawing methods. 1997. 8. M. Suter. Immunohistochemische Darstellung des “Contraception associated protein 1”, CAP1. 2001. Immunocytochemical localisation of ‘Contraception associated protein 1’, CAP1. 2002. 9. C. Avram. Relationship of the proto-oncogene c-ros to the development of the initial segment in the murine epididymis. In preparation 10. M. Anapolski. Studies on the regulation of sperm volume in fertile wild type and infertile c-ros knockout mice and observations on human spermatozoa. submitted. 11. S. Fetic. Cytoplasmic droplets of human spermatozoa observed in wet and fixed preparations and their involvement in volume regulation of human spermatozoa. Work in progress Dr.rer.nat. theses 1. M. Hölpert. Über die Messung von -laktalbumin, Galaktosytransferase und pyrophosphatase im Nebenhoden der Ratte. 1993. Measurement of -lactalbumin, galactosyltransferase and pyrophosphatase in the rat epididymis. 1993. 2. S. Raczek. Proteinsynthese und Sekretion von Nebenhodenepithelzellen der Ratte und des Menschen in der in vitro Kulture. 1993. Protein synthesis and secretion on epididymal epithelial cells from the rat and man in in vitro culture. 1993. 3. A. Wagenfeld. Zur Physiologie der Fertilität. Experimentelle Untersuchungen am Nebenhoden fertiler und infertiler Ratten. 1997. On the physiology of fertilisation. Experimental studies of the epididymis of fertile and infertile rats. 1997. 4. W. Bone. Untersuchungen zur Glycolyse von Säugerspermien und der Bedeutung für die Fertilität. 1999. Studies on glycolysis by vertebrate sperm and its importance for fertility. 1999. 5. J. Barfield. Volume regulating sperm channels as contraceptive targets. Publications in Journals (175, 65 as first author) 1. Gago C, Tablado L, Yeung C-H, Pérez-Sánchez F, Cooper TG, Soler C (1999) Morphological characterization of ejaculated monkey (Macaca fascicularis) spermatozoa. Am J Primatol, 47, 105-115 2. Cooper TG, Atkinson AD, Nieschlag E (1999) Experience with external quality control in spermatology. Human Reproduction, 14, 765-769 3. Yeung C-H, Weinbauer GF, Cooper TG (1999) Effect of acute androgen withdrawal by GnRH antagonist on epididymal sperm motility and morphology in the cynomolgus monkey. J Androl, 20, 72-79 4. Jones AR, Cooper TG. (1999) A re-appraisal of the post-testicular antifertility action and toxicity of chlorinated antifertility compounds. Int J Androl, 22, 130-138 5. Rolf C, Cooper TG, Yeung C-H, Nieschlag E (1999) Antioxidant treatment of patients with asthenozoospemia or moderate oligoasthenozoospermia with high dose vitamin C and vitamin E: a randomized, placebo-controlled, double-blind study. Human Reproduction, 14, 1028-1033 6. Cooper TG, Yeung CH (1999) Recent chemical approaches to post-testicular, epididymal contraception. Human Reproduction Update, 5, 141-152 7. Cooper TG, Yeung CH (1999) Approaches to post-testicular contraception. Asian Journal of Andrology, 1, 29-36 8. Yeung CH, Weinbauer GF, Cooper TG (1999) Responses of monkey epididymal sperm of different maturational status to secondary messengers mediating protein tyrosine kinase phosphorylation, acrosome reaction and motility. Mol Reprod Develop, 54, 194-202 9. Yeung C-H, Sonnenberg-Riethmacher, E, Cooper, TG (1999) Infertile spermatozoa of c-ros tyrosine kinase receptor knockout mice show flagellar angulation and maturational defects in cell volume regulatory mechanisms. Biol Reprod, 61, 1062-1069 10. Cooper TG (1999) Immunology of the epididymis. Andrologia 31, 322 11. Seiler P, Cooper TG, Yeung C-H, Nieschlag E (1999) Regional variation in macrophage expression by murine epididymal basal cells and their regulation by testicular factors. J Androl, 20, 738-746 12. Bone W, Jones NG, Kamp G, Yeung, CH, Cooper TG. (2000) Effect of ornidazole on fertility of male rats: inhibition of a glycolysis-related motility pattern and zona binding required for fertilisation in vitro. J Reprod Fert, 118, 127-135 13. Cooper TG, S Weydert, C-H Yeung, C Künzl, N Sachser (2000). Maturation of epididymal spermatozoa in the non-domesticated guinea pigs Cavia aperea and Galea musteloides, J Androl, 21, 154-163. 14. Seiler P, Cooper TG, Nieschlag E (2000) Sperm number and condition affect the number of basal cells and their expression of macrophage antigen in the murine epididymis. Int J Androl, 23, 65-76. 15. Soler C, Pérez-Sánchez F, Schulze H, Bergmann M, Oberpenning F, Yeung C-H, Cooper TG (2000) Objective evaluation of the morphology of human epididymal sperm heads. Int J Androl, 23, 77-84 16. Gago C, Soler C, Pérez-Sánchez F, Yeung C-H, Cooper TG (2000) Effects of Cetrorelix on sperm morphology during migration through the epididymis in the cynomolgus macaque (Macaca fascicularis). Am J Primatol, 51, 103-117 17. Cooper TG, Jones AR (2000) The metabolism of the putative antifertility agents 3-36chloro-1-hydroxypropanone and its dimethyl ketal in the male rat. Int J Androl, 23, 243-247 18. von Eckardstein S, Cooper TG, K. Rutsch, D. Meschede, J. Hörst, E. Nieschlag (2000) Seminal plasma characteristics as indicators of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in men with obstructuve azoospermia. Fertil Steril, 73, 1226-1231 19. Yeung C-H, Wagenfeld A, E. Nieschlag & Cooper TG (2000) The cause of infertility of c-ros tyrosine kinase knockout male mice. Biol Reprod, 63, 612-618 20. Bone W and Cooper TG (2000) In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, -chlorohydrin and 1-chloro-3-hydroxypropanone. Int J Androl, 23, 243-247 21. Cooper TG (2000) Die Reifung humaner Spermien im Nebenhoden. Reproduktionsmedizin. 16, 299-309 22. Wagenfeld A, Yeung, C-H, Shivaji S, Sundareswaran VR, Aragi H, Cooper TG (2000) Expression and cellular localization of contraception asociated protein 1. J Androl, 21, 954-963. 23. Yeung CH, S Schröter, C Kirchhoff, Cooper TG (2000) Maturational changes of the CD52-like epididymal glycoprotein on cynomolgus monkey sperm and their apparent reversal in capacitation conditions. Mol Reprod Dev 57, 280-289 24. Bharadwaj A, Sengupta A, Ghosh I, Cooper TG, Weinbauer GF, Brinkworth M, Nieschlag E, Ghebrehiwet B, Peerschke EIB, Datta K (2000) Stage specific expression of the proprotein form of HABP1 during spermatogenesis in the rat. Mol Reprod Develop, 62, 223-23 25. Bone W, Jones AR, Morin C, Nieschlag E, Cooper TG (2001) Susceptibility to inhibition of glycolytic enzyme activity and motility of spermatozoa from the rat, mouse and man by proven and putative chlorinated antifertility compounds in vitro. J Androl 22, 464-470 26. Cooper TG (2001) Epididymal maturation of human spermatozoa. Chinese Nat J Androl 7, 1-9. 27. Derr P, Yeung C-H, Cooper TG, Kirchhoff C (2001) Synthesis and glycosylation of CD52, the major ‘maturation-associated’ antigen of rat spermatozoa, in the cauda epididymidis. Reproduction 121, 435-446. 28. Yeung CH, Pérez-Sánchez F, Schröter S, Kirchhoff C, Cooper TG (2001) Changes of the major sperm maturation-associated epididymal protein HE5 (CD52) on human ejaculated spermatozoa during incubation. Mol Human Reprod 7, 617-624. 29. Yeung C-H, Cooper TG (2001) Effects of the ion-channel blocker quinine on human sperm volume, kinematics and mucus penetration, and the involvement of potassium channels. Mol Human Reprod 7, 819-828. 30. Cooper TG, Yeung C-H, Jones R, Orgebin-Crist, M-C, Robaire B (2002) Rebuttal of a role for the epididymis in sperm quality control by phagocytosis of defective sperm. J Cell Sci, 115, 5-7. 31. Holschbach C, Nieschlag E, Cooper TG (2002) Possible extratubular origin of epididymal basal cells. Reproduction 121, 517-525. 32. Bone W, Jones AR, Nieschlag E, Cooper TG (2002) The effect of (R,S)-ornidazole on the fertility of male mice and the excretion and metabolism of 36Cl-(R,S) a-chlorohydrin in male mice and rats. Int J Androl, 25, 94-99. 33. Jones AR, Morin C, Bone W, Nieschlag E, Cooper TG (2002) Lack of antifertility properties of novel halogenated glycolytic inhibitors and the urinary excretion and metabolism of 1,6-dichloro-1,6-dideoxy-fructofuronose in the male rat. Int J Androl, 25, 168-174. 34. Christova Y, James PS, Cooper TG, Jones R (2002) Lipid diffusion in the plasma membrane of mouse spermatozoa. Changes during epididymal maturation, effects of pH, osmotic pressure and knockout of the c-ros gene, J Androl, 23, 384-392. 35. Cooper TG (2002) Recent advances in sperm maturation in the human epididymis. Andrologie 12, 38-51. 36. Cooper TG (2002) Données récentes sur la maturation des spermatozoïdes dans l’epididyme humain. Andrologie 12, 52-67. 37. Yeung CH, Anapolski M, Cooper TG (2002) Measurement of volume changes in mouse spermatozoa using an electronic sizing analyser and a flow cytometer: validation and application to an infertile mouse model. J Androl, 23, 522-528. 38. Yeung CH, Anapolski M, Sipilä P, Wagenfeld A, Poutanen M, Huhtaniemi I, Nieschlag E, Cooper TG (2002) Sperm volume regulation: maturational changes in fertile and infertile transgenic mice and association with kinematics and tail angulation. Biol Reprod, 67, 269-275. 39. Cooper TG, Vreeburg J, Björndahl L, Nieschlag E (2002). Semen analysis and external quality control schemes for semen analysis need global standardisation. Int J Androl, 25:306-311. 40. Wagenfeld A, Yeung C-H, Lehnert W, Nieschlag E, Cooper TG (2002) Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice. J Androl, 23:772-82. 41. Sipilä P, Cooper TG, Yeung C-H, Mustonen M, Penttinen J, Drevet J, Huhtaniemi I, Poutanen M (2002) Epididymal dysfunction initiated by the expression of Simian Virus 40 T-antigen leads to angulated sperm flagella and infertility in transgenic mice. Mol Endocrinol, 16, 2603-2617 42. Hohoff C, Solmsdorff K, Löttker P, Kemme K, Epplen JT, Cooper TG, Sachser N (2002). Monogamy in a new species of wild guinea pigs. Naturwissenschaften, 89, 462-465. 43. 2003 44. Xu Y-X, Wagenfeld A, Yeung C-H, Lehnert W, Nieschlag E, Cooper TG (2003a) Expression and location of the taurine transporter in the epididymis of infertile c-ros receptor tyrosine kinase-deficient and fertile heterozygous mice. Mol Reprod Develop, 64, 144-151 45. Yeung CH, Anapolski M, Depenbusch M, Zitzmann M, Cooper TG (2003) Human sperm volume regulation. Response to physiological changes in osmolality, channel blockers and potential sperm osmolytes. Human Reprod, 18, 1029-1036 46. Cooper TG, Yeung C-H (2003a) Acquisition of volume regulatory response of sperm upon maturation in the epididymis and the role of the cytoplasmic droplet. Microscopy Research & Technique, 61, 28-38. 47. Soler C, de Monserrat JJ, Gutiérrez R, Nuñez J, Nuñez F, Pérez-Sánchez F, Cooper TG (2003) Use of the Sperm-Class Analyser® for objective assessment of human sperm morphology. Optimisation of sperm preparation. Int J Androl, 26, 262-270 48. Andersen OM, Yeung C-H, Vorum H, Wellner M, Andreassen TK, Erdmann B, Mueller E-C, Herz J, Otto A, Cooper TG, Willnow TE (2003) Essential role of the Apolipoprotein E receptor-2 in sperm development. J Biol Chem, 278, 23989-23995 49. Cooper TG, Wagenfeld A, Cornwall GA, Hsia N, Chu ST, Orgebin-Crist M-C, Drevet J, Vernet P, Avram C, Nieschlag E, Yeung C-H (2003) Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice. Biol Reprod, 69, 1750-1762 50. Xu YX, Yeung C-H, Setiawan I, Avram C, Biber J, Wagenfeld A, Lang F, Cooper TG (2003b) Sodium-inorganic phosphate cotransporter NaPi-IIb in the epididymis and its potential role in male fertility studied in a transgenic mouse model. Biol Reprod, 69, 1135-1141 51. Byrne MM, Rolf C, Depenbusch M, Cooper TG, Nieschlag E (2003) Lack of effect of a single i.v. dose of oxytocin on sperm output in severely oligozoospermic men. Human Reproduction 18, 2098-2102 52. Cooper TG (2003) Erfahrungen mit QuaDeGA. Med Review 9, 3-4. 53. Yeung CH, Anapolski M, Cooper TG (2004a) Effects of putative epididymal osmolytes and the ion channel blocker quinine on sperm volume regulation of fertile and infertile transgenic mice. J Androl, 25, 216-233 54. Allen T, Bertshinger H, Cooper TG, Cowan P, Enright W, Fayrer-Hosken R, Foggin C, Grootenhuis A, Heesterbeck H, Hildebrandt T, Hinds L, Hofmeyr M, Kahumbu P, Kamischke A, Kirkpatrick J, Lincoln G, Nett T, Stout T, Turkstra J, Whyte I. (2004) Managing African elephant populations; act or let die? http://elephantpopulationcontrol.library.uu.nl/ 55. Yeung CH, Breton S, Setiawan I, Xu Y, Lang F, Cooper TG (2004) Increased luminal pH in the epididymis of infertile c-ros knockout mice and the exression of sodium-hydrogen exchangers and vacuolar proton pump H+-ATPase. Mol Reprod Develop, 68, 159-168 56. Cooper TG, Yeung, CH, Wagenfeld A, Nieschlag E, Poutanen M, Huhtaniemi I, Sipilä P (2004) Mouse models of infertility due to swollen spermatozoa. Mol Cell Endocr, 216, 55-63 57. Christova Y, James P, Mackie A, Cooper TG, Jones R (2004) Molecular diffusion in sperm plasma membranes during epididymal maturation, Mol Cell Endocr, 216, 41-46. 58. Baart EB, van der Heijden GW, van der Hoeven FA, Bakker R, Cooper TG, de Boer P (2004) Reduced oocyte activation and first cleavage rate after ICSI with spermatozoa from a sterile mouse chromosome mutant. Hum Reoprod 19, 1140-1147. 59. Avram CE, Cooper TG (2004) Development of the caput epididymidis studied by expressed proteins (a glutamate transporter, a lipocalin and b-galactosidase) in the c-ros knockout and wild-type mice with prepubertally ligated efferent ducts. Cell Tiss Res, 317, 23-34. 60. Avram CE, Yeung, C-H, Nieschlag E, Cooper TG (2004) Regulation of the initial segment of the murine epididymis by dihydrotestosterone and testicular exocrine secretions studied by expression of specific proteins and gene expression. Cell Tiss Res 317, 13-22. 61. Yeung CH, Barfield JP, Anapolski M, Cooper TG (2004) Volume regulation of mature and immature spermatozoa in a primate model and possible ion channels involved. Human Reproduction, Epub ahead of print. 62. Cooper TG, Yeung CH, Fetic S, Sobhani A, Nieschlag E (2004) Cytoplasmic droplets are normal structures of human spermatozoa but are not well preserved by routine procedures for assessing sperm morphology. Human Reproduction, Epub ahead of print Publications in Books (27, 16 as first author) 1. Cooper TG (1999) Epididymis. Encyclopedia of Reproduction. Neill, J,D; Knobil, E, Editors. Academic Press, San Diego. Vol. 2, pp. 1-17 2. Yeung C-H, Sonnenberg-Riethmacher E, Cooper TG (1998) Receptor tyrosine kinase c-ros knockout mice as a model for the study of epididymal regulation of sperm function. The Epididymis: cellular and molecular aspects. Eds RC Jones, MK Holland, C Doberska. J Reprod Fert Suppl 53, 137-147 3. Cooper TG, Yeung C-H (1999) Sperm maturation in the primate epididymis. Weinbauer GF, Korte R (eds.) Reproduction in nonhuman primates, Waxmann Verlag, Münster, 61-78 4. Nieschag E, Weinbauer GF, Cooper TG, Wittkowski W (1999) Reproduktion. In Physiologie, Edn 3, pp. 521-539, Deetjen, P, Speckmann, E-J (eds) Urban & Schwarzenberg, München. 5. Weinbauer GFW, Cooper TG (2000) Assessment of male fertility impairment in the macaque model, Corte R; Weinbauer GF, (eds.) Towards new horizons in primate toxicology, Waxman Verlag, Münster, pp.13-42 6. Cooper TG, Yeung, C-H (2000) Physiologie der Spermienreifung und Fertilisation. In: Andrologie. Grundlagen und Klinik der reproduktiven Gesundheit des Mannes. E. Nieschlag, H.M. Behre, editors. Springer, Berlin, pp. 69-90.in press 7. Cooper TG Yeung, C-H (2000) Physiology of sperm maturation and fertilization. In Andrology. Male reproductive health and dysfunction. Nieschlag E, Behre HM, Eds. Springer, Berlin, pp. 63-82. 8. Cooper TG (2002) The epididymis as a target for male contraception. In The Epididymis. From molecules to clinical practice. A comprehensive survey of the efferent ducts, the epididymis and the vas deferens. Robaire B, Hinton BT, eds. Kluwer Academic/Plenum Publishers, New York, pp.483-502. 9. Yeung C-H, Cooper TG (2002) Acquisition and development of sperm motility upon maturation in the epididymis. In The Epididymis. From molecules to clinical practice. A comprehensive survey of the efferent ducts, the epididymis and the vas deferens. Robaire B, Hinton BT, eds. Kluwer Academic/Plenum Publishers, New York, pp.417-434. 10. Cooper TG (2002) Epididymal approaches to male contraception. In Andrology in the 21st century. Proceedings of the VIIth International Congress of Andrology, Montréal. B. Robaire, H Chemes, C.R. Morales Eds. Medomond Medical Publications, New Jersey, pp. 499-509. 11. Yeung C-H, Cooper TG (2002) Cell Volume Regulation by Mammalian Spermatozoa. In: Proceedings of the 9th International Symposium on Spermatology (Cape Town, October 2002). Van der Horst, G; Franken, D; Bornman, R; De Jager, T; Dyer, S (editors), Medimond Inc, Bologna, pp. 167-172. 12. Cooper TG, Yeung C-H (2003b) Approaches to post-testicular contraception: insights from the infertile c-ros knockout mouse. In: The third international conference on the Epididymis. Hinton BT, Turner TT, eds., Van Doren Company, Charlottesville. III. pp. 208-221. 13. Yeung, C-G, Cooper TG (2003) Developmental changes in signalling transduction factors in maturing sperm during epididymal transit. In: Signal transduction and Gamete Function, Special Issue of Cellular and Molecular Biology. 49, 341-349, Guest Editor S Shivaji.
