Curriculum Vitae - Universitätsklinikum Tübingen

Dr. med. Florian G. Metzger
Oberarzt
Tel. 07071 29-87441
Fax. 07071 29-4141
Ausbildung / Werdegang
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1998-2004: Studium der Medizin (Bayerische Julius-Maximilians-Universität
Würzburg)
2005-2010: Assistenzarzt (Klinik für Psychiatrie, Psychosomatik und
Psychotherapie; Klinik für Neurologie, Universitätsklinikum Würzburg)
2010: Facharzt für Psychiatrie und Psychotherapie
2010-heute: Oberarzt (Klinik für Psychiatrie und Psychotherapie,
Universitätsklinikum Tübingen)
Forschungsinteressen
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Früherkennung neurodegenerativer Erkrankungen
somatosensorisch evozierte Potentiale des Vagusnerven (VSEP)
Nahinfrarotspektroskopie (NIRS)
Gerontopsychiatrische Versorgungsforschung
Publikationen
Metzger, F. G., Ehlis, A.-C., Haeussinger, F. B., Schneeweiss, P., Hudak, J., Fallgatter,
A. J. & Schneider, S. (2017). Functional brain imaging of Walking while Talking - an
fNIRS study. Neuroscience, 343, 85-93.
Yilmaz, R., Pilotto, A., Roeben, B., Preische, O., Suenkel, U., Heinzel, S., Metzger, F.
G., Laske, C., Maetzler, W. & Berg D. (in press). Structural Ultrasound of the Medial
Temporal Lobe in Alzheimer's Disease. Ultraschall in Medicine.
Geib, J., Rieger, M. A., Joos, S., Eschweiler, G. W. & Metzger, F. G. (in press).
Implementierung von Ohrakupunktur nach dem NADA-Protokoll bei geriatrischen
Patienten mit einer depressiven Episode: Eine Machbarkeitsstudie mit gemischten
Methoden [Implementation of auricular acupuncture by the NADA protocol in geriatric
patients suffering from major depression : A mixed methods feasibility study].
Zeitschrift für Gerontologie und Geriatrie.
Wilke, C., Gillardon, F., Deuschle, C., Hobert, M. A.., Jansen, I. E., Metzger F. G.,
Heutink, P., Gasser, T., Maetzler, W., Blauwendraat, C. & Synofzik M. (2017).
Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRNNegative Frontotemporal Dementia. Neurodegenerative Diseases, 17, 83-88.
Metzger, F. G., Schopp, B., Haeussinger, F. B., Dehnen, K., Synofzik, M., Fallgatter, A.
J. & Ehlis, A.-C. (2016). Brain activation in frontotemporal and Alzheimer's dementia:
a functional near-infrared spectroscopy study. Alzheimers Research & Therapy, 8, 56.
Yilmaz, R., Gräber, S., Roeben, B., Suenkel, U., Thaler, A.-K., Heinzel, S., Metzger, F.
G., Eschweiler, G. W., Maetzler, W., Berg D., Liepelt-Scarfone, I. (2016). Cognitive
Performance Patterns in Healthy Individuals with Substantia Nigra Hyperechogenicity
and Early Parkinson’s Disease. Frontiers in Aging Neuroscience, 8, 271.
Metzger, F. G., Hobert, M. A., Ehlis, A.-C., Hasmann, S. E., Hahn, T., Eschweiler, G.
W., Berg, D., Fallgatter, A. J., Maetzler, W. & the TREND Study team (2016). Dual
Tasking for the Differentiation between Depression and Mild Cognitive Impairment.
Frontiers in Aging Neuroscience, 8, 235.
Lerche, S., Brockmann, K., Pilotto, A., Wurster, I., Sünkel, U., Hobert, M. A., von Thaler,
A. K., Schulte, C., Stoops, E., Vanderstichele, H., Herbst, V., Brix, B., Eschweiler, G.
W., Metzger, F. G., Maetzler, W. & Berg, D. (2016). Prospective longitudinal course
of cognition in older subjects with mild parkinsonian signs. Alzheimer's Research &
Therapy, 8, 42.
Wagner, C. J., Metzger, F. G., Sievers, C., Marschall. U., L'hoest, H., Stollenwerk, B. &
Stock S. (2016). Depression-related treatment and costs in Germany: Do they
change with comorbidity? A claims data analysis. Journal of Affective Disorders, 193,
257-266.
Rosenbaum, D., Hagen, K., Deppermann, S., Kroczek, A. M., Haeussinger, F. B.,
Heinzel, S., Berg, D., Fallgatter, A. J., Metzger, F. G., Ehlis, A.-C. & The TREND
Study Consortium (2016). State dependent altered connectivity in late-life
depression: A functional near-infrared spectroscopy study. Neurobiology of Aging, 39,
57-68.
Blauwendraat, C., Wilke, C., Jansen, I. E., Schulte, C., Simón-Sánchez, J., Metzger, F.
G., Bender, B., Gasser, T., Maetzler, W., Rizzu, P., Heutink, P. & Synofzik M. (2016).
Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort
reveals a substantial frequency of PSEN2 variants. Neurobiology of Aging, 37,
208.e11-208.e17.
Metzger, F. G., Ehlis, A.-C., Haeussinger, F. B., Fallgatter, A. J. & Hagen, K. (2015).
Effects of cholinesterase inhibitor on brain activation in Alzheimer's patients measured
with functional near-infrared spectroscopy. Psychopharmacology, 232(23), 43834391.
Heinzel, S., Metzger, F. G., Ehlis, A.-C., Korell, R., Alboji, A., Haeussinger, F.B.,
Wurster, I., Brockmann, K., Suenkel, U., Eschweiler, G. W., Maetzler, W., Berg, D. &
Fallgatter, A. J. (2015). Age and Vascular Burden Determinants of Cortical
Hemodynamics Underlying Verbal Fluency. PLoS One, 10(9), e0138863.
Hagen, K., Ehlis, A.-C., Haeussinger, F. B., Beeretz, S., Kromer, G. V., Heinzel, S.,
Maetzler, W., Eschweiler, G. W., Berg, D., Fallgatter, A. J., Metzger, F. G. & The
TREND Study Consortium (2015). The relation of SMI and the VSEP in a risk sample
for neurodegenerative disorders. Journal of Neural Transmission, 122(8), 1167-1174.
Geib, J., Rieger, M. A., Joos, S., Eschweiler, G. W., Dresler, T. & Metzger, F. G. (2015).
Introduction of auricular acupuncture in elderly patients suffering from major
depression - protocol of a mixed methods feasibility study. BioMed Research
International, 2015, 678410.
Heinzel, S., Liepelt-Scarfone, I., Roeben, B., Nasi-Kordhishti, I., Suenkel, U., Wurster,
I., Brockmann, K., Fritsche, A., Niebler, R., Metzger, F. G., Eschweiler, G. W.,
Fallgatter, A. J., Maetzler W. & Berg, D. (2014). A neurodegenerative vascular burden
index and the impact on cognition. Frontiers in Aging Neuroscience, 6, 191.
Polak, T., Metzger, F. G., Deckert, J., Fallgatter, A. J. (2014). Central neural versus
peripheral muscular origin of vagus somatosensory - evoked potentials. Brain
Stimulation, 7(4), 624-625.
Hagen, K., Ehlis, A.-C., Schneider, S., Haeussinger, F. B., Fallgatter, A. J. & Metzger,
F. G. (2014). Influence of different stimulation parameters on the somatosensory
evoked potentials of the nervus vagus - How varied stimulation parameters affect
VSEP. Journal of Clinical Neurophysiology, 31(2), 143-148.
Polak, T., Dresler, T., Zeller, J. B. M., Warrings, B., Scheuerpflug, P., Fallgatter, A. J.,
Deckert, J. & Metzger, F. G. (2014). Vagus somatosensory evoked potentials are
delayed in Alzheimer´s disease, but not in major depression. European Archives of
Psychiatry and Clinical Neurosciences, 264(3), 263-276.
Hagen, K., Ehlis, A.-C., Haeussinger, F. B., Heinzel, S., Dresler, T., Müller, L. D.,
Herrmann, M. J., Fallgatter, A. J. & Metzger, F. G. (2014). Activation during the Trail
Making Test measured with functional near-infrared spectroscopy in elderly healthy
subjects. Neuroimage, 85(1), 583-591.
Schneider, S., Bahmer, T. J., Metzger, F. G., Reif, A., Polak, T., Pfuhlmann, B., Walter,
A., Eberle, M.-C., Ernst, L. H., Fallgatter, A. J. & Ehlis, A.-C. (2013). Quetiapine and
flupentixol differentially improve anterior cingulate cortex (ACC) function in
schizophrenia patients – An event-related potential (ERP) study. International Journal
of Neuropsychopharmacology, 16(9), 1911-1925.
Heinzel, S., Metzger, F.G., Ehlis, A.-C., Korell, R., Alboji, A., Haeussinger, F. B., Hagen,
K., Maetzler, W., Eschweiler, G. W., Berg, D., Fallgatter, A. J. & the TREND study
consortium (2013). Aging-related cortical reorganization of verbal fluency processing:
an fNIRS study. Neurobiology of Aging, 34(2), 439-450.
Polak, T., Zeller, D., Fallgatter, A. .J. & Metzger, F. G. (2013). Vagus somatosensoryevoked potentials are prolonged in patients with multiple sclerosis with brainstem
involvement. Neuroreport, 4(5), 251-253.
Synofzik, M., Biskup, S., Leyhe, T., Reimold, M., Fallgatter, A. J & Metzger, F. (2012).
Suicide attempt as the presenting symptom of c9orf72 dementia. American Journal of
Psychiatry, 169(11), 1211-1213.
Metzger, F., Polak, T., Aghazadeh, Y., Ehlis, A.-C., Hagen, K. & Fallgatter, A. J. (2012).
Vagus somatosensory evoked potentials – a possibility for diagnostic improvement in
patients with mild cognitive impairment? Dementia and Geriatric Cognitive Disorders,
3(5), 289-296.
Polak, T., Weise, D., Metzger, F., Ehlis, A.-C., Langer, J. B. M., Schramm, A., Fallgatter,
A. J. & Classen J. (2011). Vagus nerve somatosensory evoked potentials in
Parkinson's disease. Journal of Neurology, 258(12), 2276-2277.
Polak, T., Markulin, F., Ehlis, A.-C., Metzger, F., Langer, J. B. M., Ringel, T. M. &
Fallgatter, A. J. (2009). Auricular vagus somatosensory evoked potentials in vascular
dementia. Journal of Neural Transmission, 116(4), 473-477.
Schecklmann, M., Ehlis, A.-C., Plichta, M. M., Boutter, H. K., Metzger, F. G. & Fallgatter
A. J. (2007). Altered frontal brain oxygenation in detoxified alcohol dependent
patients with unaffected verbal fluency performance. Psychiatry Research:
Neuroimaging, 156, 129-138.
Polak, T., Ehlis, A.-C., Langer, J. M. B., Plichta, M. M., Metzger, F., Ringel, T. M. &
Fallgatter, A. J. (2007). Non-invasive measurement of vagus activity in the brainstem
– a methodological progress towards earlier diagnosis of dementias? Journal of Neural
Transmission, 110, 1437-1443.
Fallgatter, A. J., Polak, T., Metzger, F., Richter, M. M., Baehne, C. G., Plichta, M. M.,
Scheuerpflug, P. & Ehlis, A.-C. (2006). Brainstem vagus nuclei evoked potentials – a
new diagnostic method in neuropsychiatry? Nervenheilkunde, 25, 669 - 673
Kongressbeiträge
Metzger F., Polak T., Hagen K., Ehlis A.-C. (2011). Vagus somatosensory-evoked
potentials: a non-invasive diagnostic possibility for patients with mild cognitive
impairment? Alzheimer's & Dementia: The Journal of the Alzheimer's Association,
7(4), Supplement, S541-S542 (Poster Alzheimer’s Association International
Conference in Paris, July 2011)
Metzger F., Polak T., Ehlis A.-C., Aghazadeh Y., Hagen K. & Fallgatter A. J. (2011).
Somatosensorisch evozierte Potenziale des Nervus Vagus – eine nichtinvasive
diagnostische Möglichkeit für Patienten mit leichter kognitiver Beeinträchtigung?
(Poster Kongress der Deutschen Gesellschaft für Psychiatrie, Psychotherapie und
Nervenheilkunde in Berlin, Nov. 2011)