Cyclin G is involved in meiotic checkpoint control in Drosophila

LIFE SCIENCE CENTER (760)
Biologische Signale
Cyclin G is involved in
meiotic checkpoint
control in Drosophila
melanogaster
allposters.de
presented by
Prof. Dr. Anette Preiss
Universität Hohenheim, Fg. Allgemeine Genetik
Donnerstag, 6. Dezember 2012, 17:15 Uhr
Hörsaal Ö1, Universität Hohenheim
www.lsc.uni-hohenheim.de
LIFE SCIENCE CENTER (760)
Biologische Signale
“Cyclin G is involved in meiotic checkpoint
control in Drosophila melanogaster”
Prof. Dr. Anette Preiss
Universität Hohenheim
Fg. Allgemeine Genetik
In general, cyclins control the cell cycle. Not so the atypical cyclins, which are required
for diverse cellular functions such as for genome stability or for the regulation of
transcription and translation. The scientists are studying the atypical Cyclin G (CycG)
gene of Drosophila. The two mammalian CycG genes, CycG1 and CycG2, regulate
the cell cycle in response to cell stress, yet with apparently opposite effects.
In order to analyse the role of the single Drosophila CycG gene, they generated a null
mutant by homologous recombination. The mutant flies are homozygous viable,
however, the mutant females are sterile and produce ventralized eggs. This egg
phenotype is primarily a consequence of a defective Epidermal Growth Factor
Receptor (EGFR) signalling pathway. They find that CycG is required within the oocyte
where it is involved in the translation of the EGFR-ligand Grk. Ventralized eggs are
also observed in mutants that are defective in meiotic DNA double-strand break repair.
Altogether the data indicate a role for CycG in an early step of meiotic recombination
repair, thereby affecting EGFR-mediated patterning processes during oogenesis.
Donnerstag, 6. Dezember 2012, 17:15 Uhr
Hörsaal Ö1, Universität Hohenheim
www.lsc.uni-hohenheim.de