Novartis Stiftung für medizinisch-biologische Forschung: Bewilligte Projekte 2006 No Name Institut Projekt 06A02 Trendelenburg M., Dr. Innere Medizin B & Klinische Immunologie, Universitätsspital Basel SLE cohort: The role of autoantibodies against complement C1q in the follow-up 06A03 Heizmann C.W., Prof. Abt. Für Klinische Chemie und Biochemie, Universitäts-Kinderklinik Zürich Myocardial calcium signalling and the importance of S100A1 in pathogenesis 06A04 Berger Th., PD Dr. Inst. Für Physiologie, Universität Bern Informationsverarbeitung in Neuronen und Netzwerken in kortikalen Hirnschnitten unter in vivo-ähnlichen Bedingungen 06A08 Siler U., Dr. Abt. Immunologie/Hämatologie/KMT, Kinderspital Zürich Development of a gammaretroviral vector for gene replacement therapy of the p47 phox-deficient form of chronic granulomatous disease (CGD) 06A09 Thome-Miazza M., Prof. Dép. de Biochimie, Université de Lausanne Analysis of signaling pathways that control NF-kB activation and cytokine production in monocytes 06A10 Thöny B., Prof. Abt. Für Klinische Chemie und Biochemie, Universitäts-Kinderklinik Zürich Genetherapy for phenylketonuria (PKU) with an hepatic rAAV-8 vector: from mice to clinic 06A11 Gross N., PD Dr. Lab. De Recherche en Oncologie Pédiatrique, Dép. Médico-chirurgical de Pédiatrie, CHUV, Lausanne An in vitro and in vivo study to target neuroblastoma apoptosis and angiogenesis by histone deacetylase inhibitors 06A14 De Moerloose Ph., Prof. Div. d’Angiologie et d’Hémostase, Hôpital Cantonal Univ. de Genève Role of toll-like receptors in endothelial cell activation by antiphospholipid antibodies 06A16 Féraille E., PD Dr. Service de Néphrologie, fondation pour recherches médicales, Université de Genève Role of local pro-inflammatory stimuli in the pathogenesis of sodium retention in nephrotic syndrome 06A19 Orend G., PD Dr. Inst. Für Biochemie und Genetik, Zentrum für Biomedizin, DKBW, Universität Basel Analysis of the role of FAK, RhoA and tropomyosin-1 in cell adhesion signaling downstream of syndecan-4 in a tenascin-C context 06A20 Loewith R., Prof. Dép. de Biologie Moléculaire, Université de Genève SCH9 and YPK2 as TOR complexes effectors 06A24 Thelen M., Prof. PD Dr. Istituto di Ricerca in Biomedicina, Bellinzona Chemokine receptor mediated signal transduction 06A28 Heuer N., Dr. & Hatz Ch., Prof. Swiss Tropical Institute, Basel Antiretroviral Therapy at St. Francis designated district Hospital: Treatment outcome depending on the baseline CD4 cell count of late presenters 06A29 Went Ph., Dr. & Dirnhofer S., Prof. Inst. Für Pathologie, Universität Basel Genotype - phenotype correlation in peripheral T-cell lymphomas 06B33 Heinimann K., PD Dr. Forschungsgruppe Humangenetik, Abt. Medizinische Genetik UKBB, Zentrum für Biomedizin DKBW, Universität Basel Gene expression profiling in autosomal recessive Hutchinson-Gilford progeria syndrome (HGPS) 06B36 James R., Prof. Dept. Of Internal Medicine, Medical Faculty, University of Geneva The role of paraoxonase gene family in protection against bacterial infection 06B37 Serra A., Dr. Klinik für Nephrologie, Universitätsspital Zürich Inhibition of the mammalian target of rapamycin (mTOR) to slow the progression of autosomal dominant polycystic kidney disease (ADPKD) 06B39 Hemphill A., Prof. Institut für Parasitologie, Vetsuisse Fakultät, Universität Bern Echinococcus and echinococcosis: development of novel treatments for an old disease 06B41 Kapfhammer J., Prof. Anatomisches Institut, Universität Basel Synaptic and dendritic development of the cerebellar Purkinje cells in GluRδ2 (GRID2) mutant mice: Focus on autophagy and glutamate receptors 06B43 Huwiler A., Prof. Institut für Pharmakologie, Universität Bern Regulatory functions of sphingolipids in inflammatory eicosanoid synthesis in macrophages 06B44 Ruiz i Altaba A., Prof. , Faculté de Médecine, Dép. de Médecine Génétique et Développement, Université de Genève Characterization and imaging of Gli1+cells of the subventricular zone of mouse brain 06B45 Brink M., Prof. Dept. Für Klinische und Biologische Wissenschaften (DKBW), Dept. Forschung, Universitätsspital Basel Transcriptional Regulation of the Urocortin II Gene in the Cardiovascular System 06B48 Boyman O., Dr. Institut Ludwig de Recherche sur le Cancer, Université de Lausanne Use of interleukin 2 in CD8+ cell-based vaccination 06B50 Nadal D., Prof. Infektiologie, Universitätskinderklinik Zürich Regulation of Epstein-Barr virus lytic infection by latent membrane protein (LMP)2A and LMP2B 06B51 Meyer H., Dr. Insitut für Biochemie, ETH Zürich Regulation of mitosis in human cells by valosin-containing protein (VCP)/p97 06B52 Papassotiropoulos A., Prof. Abt. Für Psychiatrische Forschung, Universität Zürich The influence of cAMP-dependent protein kinase (PRKACG) on human memory 06B53 Stickel F., PD Dr. Institut für Klinische Pharmakologie, Universität Bern Auswirkung chronischer Alkoholzufuhr auf die Leberfibroseprogression bei Leptinrezeptor-defekten, adipösen fa/faZucker-Ratten 06B54 Kretz R., Prof. Dept. Medizin, Abt. Anatomie, Universität Fribourg TUP-FOS 06C56 Hohl D., Prof. Service de Dermatologie, CHUV, Lausanne Développement d’un modèle organotypique modulable in vitro pour l’ichtyose lamellaire de type et l’ichtyose létale arlequin 06C59 Sommer Lukas, Prof. Insitut für Zellbiologie, ETH Zürich The developmental and therapeutic potential of neural-crest-derived adult stem cells from the skin 06C62 Lang U., PD Dr. Service d’endocrinologie, diabétologie et nutrition, HUG, Genève Role of HDL in antiapoptotic and hypertrophic responses in ventricular cardiomyocytes 06C64 Stein J.V., Dr. Theodor Kocher Institut, Universität Bern Developing optical projection tomography for three-dimensional tissue analysis of secondary lymphoid organs 06C67 Wymann M., Prof. Inst. für Biochemie und Genetik, Dept. für Klinische und Biologische Wissenschaften, Zentrum für Biomedizin, Universität Basel Role of class I PI3Ks in natural killer cells 06C69 Zurn A., PD Dr. Service de Chirurgie Expérimentale, CHUV, Faculté de Biologie et Médecine, Lausanne Molecular analysis of the glial response to injury: use of laser capture microdissection and real-time RT-PCR to evaluate the regulation of candidate molecules involved in axonal growth-inhibition 06C71 Swartz M., Prof. Institute of Bioengineering, School of Life Sciences, EPFL, Lausanne Tumor cell homing into the lymphatics via autologous chemokine signaling and interstitial flow 06C73 Giusti V., PD Dr. Service d?Endocrinologie, Diabétologie et Métabolisme, CHUV, Université de Lausanne Role of the 11β-hydroxysteroid dehydrogenase in the pathologenesis of obesity and the metabolic syndrome 06C77 Fraefel C., PD Dr. Virologisches Institut, Vetsuisse Fakultät, Universität Zürich Adeno-associated virus-mediated inhibition of helper virus replication: what is the role of Rep-mediated effects on the host cell? 06C79 Geisler M., Prof. Inst. Für Pflanzenbiologie, Molekulare Pflanzenphysiologie, Universität Zürich Watching TWISTED DWARF1 at work: Imaging p-glycoprotein-mediated auxin transport 06C81 Neuhauss S., Prof. Zoologisches Institut, Universität Zürich Adult Zebrafish as model organism for retinal diseases 06C82 Bochaton-Piallat M.L., PD Dr. Dép. de Pathologie et Immunologie, Faculté de Médecine, CMU, Université de Genève Human atherosclerotic plaque and restenostic lesion characterization: role of S100A4, a marker of activated smooth muscle cells 06C83 Trampuz A., Dr. Klinik für Infektiologie & Spitalhygiene, Universitätsspital Basel Calorimetry - A novel method for rapid detection of microorganisms in patient blood and other body fluids 06C84 Tichelli A., Prof. & Kalberer Ch., Dr. Hämatologie Labor und Stem Cell Transplantation Team, Universitätsspital Basel Development of clinical immunotherapy with activated natural killer cells for acute leukemia