Prof. Dr. Hans-Georg Kräusslich 11/02/1958, Passau

Prof. Dr. Hans-Georg Kräusslich
Department of Virology
University of Heidelberg
69120 Heidelberg, Germany
Phone: +49-(0)6221-56 5002
Fax: +49-(0)6221-56 5003
E-mail: [email protected]
11/02/1958, Passau
CURRICULUM VITAE
2004 – present
2004 – present
2000 – present
1996 – 1999
1995 – 1999
1994
1993 – 1995
1993
1990
1989 – 1993
1986 – 1989
1985
1977 – 1984
Director Hygiene-Institute, University of Heidelberg
Coordinator research program “Infectious diseases”, University of
Heidelberg
Full professor and head of department for virology, University of Heidelberg
Director, Heinrich-Pette-Institute, Hamburg
Full professor and head of department, Heinrich-Pette-Institute, Hamburg
Offer for full professorship at the University of Ulm, declined
Head of junior department, German Cancer Research Centre, Heidelberg
Offer for full professorship at the University of Münster, declined
Habilitation, University of Heidelberg
Group leader, German Cancer Research Centre, Heidelberg
Postdoc, Dept of Molecular Biology, State University New York at Stony
Brook
MD in experimental virology (Munich)
Medical School (Munich)
COORDINATING FUNCTIONS
2006 – present
2005 – present
2004 – present
2004 – present
2002 – present
2002 – 2005
2001 – 2004
1997 – 2000
1997 – 1999
1994 – 1997
Coordinator Cluster of Excellence ‘Cellular Networks’
Coordinator DFG central research program “Membrane envelopment”
Member steering committee SFB638, University of Heidelberg
Member Rektoratskommission “BIOQUANT”
Speaker SFB544 “Control of tropical infectious diseases” University of
Heidelberg
Coordinator collaborative research project “Resistance of human
pathogens” (Landesstiftung Baden-Württemberg)
Coordinator EU (FP5) collaborative project HIV protease inhibitor resistance
Member steering committee SFB545, University of Hamburg
Deputy speaker, DFG research group “RNA trafficking”
Speaker collaborative BMBF-funded AIDS-research grant University of
Heidelberg
FIELDS OF INTEREST
Molecular virology, cell biology of virus infection, HIV assembly and structure, virus entry and
uncoating, viral proteases, antiviral drugs, resistance development, prevention of viral
diseases.
CURRENTLY FUNDED PROJECTS
SFB544, projects A6 and B11; SFB638, project A9, DFG-project on kinetics on viral entry;
DFG-SPP1175; Landesstiftung Baden-Württemberg, German-Israeli-foundation, PROCOPE,
DAAD, industry-support.
PUBLICATIONS (10 most important publications since 2000):
Welsch S, Keppler OT, Habermann A, Allespach I, Krijnse-Locker J, Kräusslich HG (2007)
HIV-1 buds predominantly at the plasma membrane of primary human macrophages. PLOS
Pathog. In press.
Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Kräusslich HG (2006) The HIV
lipidome: A raft with an unusual composition. Proc Natl Acad Sci USA 103: 2641-2646.
Ternois F, Sticht J, Duquerroy S, Kräusslich HG, Rey FA (2005) Crystal structure of the HIV-1
capsid protein C-terminal domain in complex with an inhibitor of particle assembly. Nat Struct
Mol Biol 12: 678-682.
Sticht J, Humbert M, Findlow S, Bodem J, Müller B, Dietrich U, Werner J, Kräusslich HG
(2005) A Peptide Inhibitor of HIV-1 Assembly in vitro. Nat Struct Mol Biol 12: 671-677.
Briggs JAG, Simon MN, Gross I, Kräusslich HG, Fuller SD, Vogt VM, Johnson MC (2004) The
stoichiometry of Gag protein in HIV-1. Nat Struct Mol Biol 11: 672-675.
Müller B, Daecke J, Fackler OT, Dittmar MT, Zentgraf H, Kräusslich HG (2004) Generation of
a fluorescently labelled infectious HIV-1 derivative. J Virol 78: 10803-10813.
Briggs J.A.G, Wilk T, Welker R, Kräusslich HG, Fuller SD (2003) The structural organization
of authentic HIV-1 and its core. EMBO J 22: 1707-1715.
von Schwedler U, Stuchell M, Müller B, Ward D, Chung HY, Morita E, Wang HE, Davis T, He
GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI (2003) The
Protein Network of HIV Budding. Cell 114: 701-713.
Gross I, Hohenberg H, Wilk T, Wiegers K, Grättinger M, Müller B, Fuller S, Kräusslich HG
(2000) A conformational switch controlling HIV-1 morphogenesis. EMBO J 19: 103-113.
Schubert U, Ott DE, Chertova EN, Welker R, Tessmer U, Bennink JR, Kräusslich HG,
Yewdell JW (2000) Proteasome inhibition interferes with Gag polyprotein processing, release
and maturation of HIV-1 and HIV-2. Proc Natl Acad Sci USA 97: 13057-13062.
EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Member of numerous thesis and thesis advisory committees
International reviewer of doctoral theses
Supervised more than 20 doctoral theses
SUPERVISED DISSERTATIONS (last 5 years)
Marc Arnold, PhD (2006) Identifizierung und Charakterisierung von Faktoren, die beim
nukleären Export von mRNA beteiligt sind. University of Heidelberg.
Current occupation: Postdoctoral fellow, DKFZ Heidelberg.
Eva Gottwein, PhD (2005) Retroviral late domains and ubiquitination. University of
Heidelberg.
Current occupation: Postdoctoral Fellow, Duke University USA).
Sylvia Schütz, PhD (2004) Untersuchung des CRM1-abhängigen RNA-Exports mittels
repräsentativer Differenz-Analyse. University of Heidelberg.
Current occupation: Postdoctoral Fellow, Berkeley USA.
Jana Sticht, PhD (2004) HIV-1 capsid assembly and ist inhibition. University of Heidelberg.
Current occupation: Postdoctoral fellow, Humboldt-University Berlin.
Judith Gasteier, PhD (2004) Cellular functions of the HIV-Nef binding partner FHOD 1.
University of Heidelberg.
Current occupation: unknown
Sandra Reuter, PhD (2004) Charakterisierung einer Hüllprotein-vermittelten Restriktion von
HIV-2 in humanen Zellen. University of Heidelberg.
Current occupation: Postdoctoral Fellow (2006), Research Scientist
Volker
Hermann, PhD (2004) Etablierung eines infizierbaren
Untersuchung von HIV-Nef. University of Heidelberg.
Current occupation: Research Scientist
Kleintiermodells
zur
Denis M. Tebit, PhD (2002) Characterisation of Primary Isolates and Infectious Molecular
Clones of Human Immunodeficiency Virus Type 1 from Cameroon.
Current occupation: unknown
Jens Bohne, PhD (2002) Regulation von differentiellen Spleißen und RNA Export beim
humanen Immuneffizienzvirus.
Current occupation: Postdoctoral fellow, Medical University of Hannover.
Jessica Daecke, PhD (2002) Untersuchungen zur Rolle von Dynamin beim Zelleintritt von
HIV.
Current occupation: Research Scientist, Merck AG Darmstadt.
Ellen Krautkrämer, PhD, Die Bedeutung von Lipid Rafts für die Nef-vermittelten Effekte einer
HIV-1 Infektion.
Current occupation: Postdoctoral Fellow, Medical University of Heidelberg.
Sonja Welsch, PhD, Ultrastructural Analysis of HIV-1 Infection in Human Cells.
Current occupation: Postdoctoral Fellow, University of Oxford.