Publikationsliste - Pharmazeutische und Medizinische Chemie

Publikationsliste Prof. Dr. Michael Müller
(Stand 22.06.2015)
1.
A. Yenesew, Ermias Dagne, Michael Müller, Wolfgang Steglich,
An anthrone, an anthraquinone and two oxoanthrones from Kniphofia foliosa,
Phytochemistry 1994, 37, 525–528.
2.
Ermias Dagne, B. van Wyk, Michael Müller, Wolfgang Steglich,
Three dihydroanthracenones from Gasteria bicolor,
Phytochemistry 1996, 41, 795–799.
3.
Michael Wolberg, Michael Müller, Werner Hummel,
Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren sowie deren Ester,
Patent DE 198 57 302, 27.10.2000 (Patentanmeldung vom 16.12.1998).
4.
Michael Müller, Rolf Müller, Tin-Wein Yu, Heinz G. Floss,
Synthesis of (-)-3-Amino-3-deoxyquinic Acid,
J. Org. Chem. 1998, 63, 9753–9755.
5.
Thomas Dünnwald, Lasse Greiner, Hans Iding, Andreas Liese, Michael Müller, Martina Pohl,
Stereoselektive Synthese von 2-Hydroxyketonen,
Patentanmeldung DE 199 18 935.8, 26.4.1999.
6.
Michael Müller, Michael Wolberg, Werner Hummel, Christian Wandrey,
Verfahren zur Reduktion von Keto-Carbonsäuren und deren Estern.,
US Patent 6,689,591 B2, 10.02.2004 (Patentanmeldung DE 199 37 825.8, 9.7.1999).
7.
Sungsook Lee, Andreas Kirschning, Michael Müller, Chris Way, Heinz G. Floss,
Enzymatic synthesis of [7-14C, 7-3H]- and [1-13C]sedoheptulose 7-phosphate and
[1-13C]ido-heptulose 7-phosphate,
J. Mol. Catalysis B: Enzymatic 1999, 6, 369–377.
8.
Thomas Schubert, Maria-Regina Kula, Michael Müller,
Chemoenzymatic Synthesis of (S)-8-O-Methylmellein by Candida parapsilosis Carbonyl Reductase,
Synthesis 1999, 2045–2048.
9.
Ayhan S. Demir, Thomas Dünnwald, Hans Iding, Martina Pohl, Michael Müller,
Asymmetric Benzoin Reaction Catalyzed by Benzoylformate Decarboxylase,
Tetrahedron: Asymmetry 1999, 10, 4769–4774.
10. Ayhan S. Demir, Martina Pohl, Michael Müller,
Nukleotidsequenz kodierend für eine Benzaldehyd-Lyase und Verfahren zur stereoselektiven
Synthese von 2-Hydroxyketonen, Patentanmeldung DE 100 32 254.9, 30.6.2000.
11. Dirk Franke, Georg Sprenger, Rolf Müller, Ralf Takors, Volker Lorbach, Jörg Thömmes, Markus
Halfar, Michael Müller,
Verfahren zur verbesserten Herstellung und Isolierung von trans-Dihydroxycyclohexadiencarbonsäuren und/oder deren Folgeprodukte sowie ein dazu geeigneter genetisch veränderter Organismus,
Patentanmeldung DE 100 42 535.6, 30.8.2000.
12. Michael Müller, Kai Lamottke, Erich Löw, Eva Magor-Veenstra, Wolfgang Steglich,
Stereoselective total syntheses of atrochrysone, torosachrysone and related 3,4-dihydroanthracen1(2H)-ones,
J. Chem. Soc., Perkin Trans. 1 2000, 2483–2489.
13. Hans Iding, Thomas Dünnwald, Lasse Greiner, Andreas Liese, Michael Müller, Petra Siegert, Joachim
Grötzinger, Ayhan S. Demir, Martina Pohl,
Benzoylformate Decarboxylase from Pseudomonas putida as Stable Catalyst for the Synthesis of
Chiral 2-Hydroxy Ketones,
Chem. Eur. J. 2000, 6, 1483–1495.
14. Thomas Dünnwald, Ayhan S. Demir, Petra Siegert, Martina Pohl, Michael Müller,
Enantioselective Synthesis of (S)-2-Hydroxy propanone Derivatives by Benzoylformate
Decarboxylase catalyzed C-C-bond formation,
Eur. J. Org. Chem. 2000, 2161–2170.
15. Michael Wolberg, Werner Hummel, Christian Wandrey, Michael Müller,
Highly Regio- and Enantioselective Reduction of 3,5-Dioxocarboxylates,
Angew. Chem. 2000, 112, 4476–4478; Angew. Chem. Int. Ed. 2000, 39, 4306–4308.
16. Thomas Dünnwald, Michael Müller,
Stereoselective Formation of Bis(-Hydroxy Ketones) via Enzymatic Carboligation,
J. Org. Chem. 2000, 65, 8608–8612.
17. Thomas Schubert, Werner Hummel, Michael Müller,
Verfahren zur Herstellung von optisch aktiven, propargylischen, terminalen Epoxiden,
Patentanmeldung DE 101 05 866.7, 15.2.2001.
18. Silke Bode, Michael Wolberg, Michael Müller
Verfahren zur Trennung diastereomerer 1,3-Diol-Acetale,
Patentanmeldung DE 101 43 358.1, 25.9.2001.
19. Michael Müller, Wolfgang Sauer, Gunter Laban,
Verfahren zur Herstellung von (R)- und (S)-8-Chlor-6-hydroxy-octansäurealkylestern durch
enzymatische Reduktion von 8-Chlor-6-oxo-octansäurealkylestern,
Patent DE 101 52 113, 06.03.2003 (Patentanmeldung vom 23.10.2001, AWD Dresden–Viatris GmbH).
20. Tin-Wein Yu, Rolf Müller, Michael Müller, Xiaohong Zhang, Gerald Draeger, Chun-Gyu Kim, Eckhard
Leistner, Heinz G. Floss,
Mutational Analysis and Reconstitution Expression of the Biosynthetic Genes Involved in the
Formation of 3-Amino-5-hydroxybenzoic Acid, the Starter Unit of Rifamycin Biosynthesis in
Amycolatopsis mediterannei S699,
J. Biol. Chem. 2001, 276, 12546–12555.
21. Aiguo Ji, Michael Wolberg, Werner Hummel, Christian Wandrey, Michael Müller,
Dynamic kinetic resolution of tert-butyl 4-methyl-3,5-dioxohexanoate through enzymatic reduction,
Chem. Commun. 2001, 57–58.
22. Daniel Drochner, Michael Müller,
Total Synthesis of (R)- and (S)-semi-Vioxanthin,
Eur. J. Org. Chem. 2001, 211–215.
23. Dirk Franke, Georg A. Sprenger, Michael Müller,
Synthese funktionalisierter Cyclohexadien-trans-diole durch rekombinante Escherichia-coli-Zellen,
Angew. Chem. 2001, 113, 578–581; Angew. Chem. Int. Ed. 2001, 40, 555–557.
24. Ayhan S. Demir, Martina Pohl, Elena Janzen, Michael Müller,
Enantioselective synthesis of hydroxy ketones via cleavage and formation of acyloin linkage.
Enzymatic kinetic resolution via C-C bond cleavage,
J. Chem. Soc., Perkin Trans. 1 2001, 633–635.
25. Michael Wolberg, Aiguo Ji, Werner Hummel, Michael Müller,
Enzymatic reduction of hydrophobic ,-diketo esters,
Synthesis 2001, 937–942.
26. Michael Wolberg, Werner Hummel, Michael Müller,
Biocatalytic Reduction of ,-Diketo Esters: A Highly Stereoselective Approach to All Four
Stereoisomers of a Chlorinated ,-Dihydroxy Hexanoate,
Chem. Eur. J. 2001, 7, 4562–4571.
27. Thomas Schubert, Werner Hummel, Maria-Regina Kula, Michael Müller,
Enantioselective Synthesis of both Enantiomers of various Propargylic Alcohols by Use of Two
Oxidoreductases,
Eur. J. Org. Chem. 2001, 4181–4187.
28. Andreas Job, Michael Wolberg, Michael Müller, Dieter Enders,
Asymmetric Synthesis of S-(+)-Argentilactone and S-(-)-Goniothalamin,
Synlett 2001, 1796–1798.
29. Aiguo Ji, Michael Müller, Michael Wolberg, Werner Hummel, Christian Wandrey,
Chemoenzymatic Synthesis of Optically Pure tert-Butyl (4S,5R)-4-Methyl-5-hydroxy-3-oxo-hexanoate,
Chinese Journal of Organic Chemistry 2002, 22, 1009–1012.
30. Murillo Villela Filho, Michael Wolberg, Michael Müller, Werner Hummel, Andreas Liese, Christian Wandrey,
Verfahrensentwicklung zur Synthese eines -Hydroxy--ketohexanoates
Chemie Ingenieur Technik 2002, 74, 657.
31. Thomas Schubert, Werner Hummel, Michael Müller,
Highly Enantioselective Preparation of Novel Multifunctionalized Propargylic Building Blocks,
Angew. Chem. 2002, 114, 656–659; Angew. Chem. Int. Ed. 2002, 41, 634–637.
32. Silke E. Bode, Michael Müller, Michael Wolberg,
Diastereomer-differentiating hydrolysis of 1,3-diol-acetonides: a simplified procedure for the
separation of syn- and anti-1,3-diols,
Org. Lett. 2002, 4, 619–621.
33. Volker Lorbach, Dirk Franke, Martin Nieger, Michael Müller,
Cyclohexadiene-trans-diols as versatile starting material in natural product synthesis: Short and
efficient synthesis of iso-crotepoxide and ent-senepoxide,
Chem. Commun. 2002, 494–495.
34. Ayhan S. Demir, Özge Şeşenoglu, Elif Eren, Birsu Hosrik, Martina Pohl, Elena Janzen, Doris Kolter,
Ralf Feldmann, Pascal Dünkelmann, Michael Müller,
Enantioselective Synthesis of -Hydroxy Ketones via Benzaldehyde Lyase Catalyzed
C-C Bond Formation Reaction,
Adv. Synth. Catal. 2002, 344, 96–103.
35. Jose L. Vicario, Andreas Job, Michael Wolberg, Michael Müller, Dieter Enders,
Asymmetric Total Synthesis of (-)-Callystatin A Employing the SAMP/RAMP Hydrazone Alkylation
Methodology,
Org. Lett. 2002, 4, 1023–1026.
36. Dieter Enders, Jose L. Vicario, Andreas Job, Michael Wolberg, Michael Müller,
Asymmetric Total Synthesis of (-)-Callystatin A and (-)-20-epi-Callystatin A Employing the
SAMP/RAMP Hydrazone Alkylation Methodology,
Chem. Eur. J. 2002, 8, 4272–4284.
37. Pascal Dünkelmann, Doris Kolter-Jung, Adam Nitsche, Ayhan S. Demir, Petra Siegert, Bettina Lingen,
Martin Baumann, Martina Pohl, Michael Müller,
Development of a donor-acceptor concept for catalytic asymmetric cross-coupling reactions of
aldehydes: first asymmetric cross-benzoin condensation,
J. Am. Chem. Soc. 2002, 124, 12084–12085.
38. Martina Pohl, Bettina Lingen, Michael Müller,
Thiamin diphosphate-dependent Enzymes: New Aspects of Asymmetric C-C Bond Formation
Chem. Eur. J. 2002, 8, 5288–5295 (Concepts paper, invited).
39. Michael Müller, Anabel Cosp, Pascal Dünkelmann, Simon Esser, Daniel Drochner,
Highlights 2002: Enzyme in der Organischen Synthese,
Nachr. Chem. 2003, 51, 303–305.
40. Daniel Drochner, Wolfgang Hüttel, Martin Nieger, Michael Müller,
Unselective Phenolic Coupling of Methyl 2-Hydroxy-4-methoxy-6-methylbenzoate – A Valuable Tool
for the Total Synthesis of Natural Product Families,
Angew. Chem. 2003, 115, 961–963; Angew. Chem. Int. Ed. 2003, 42, 931–933.
41. Holger Wildemann, Pascal Dünkelmann, Michael Müller, Bernd Schmidt,
A short olefin metathesis-based route to enantiomerically pure arylated dihydropyrans,
J. Org. Chem. 2003, 68, 799–804.
42. Ayhan S. Demir, Özge Sesenoglu, Pascal Dünkelmann, Michael Müller,
Benzaldehyde Lyase-Catalyzed Enantioselective Carboligation of Aromatic Aldehydes with Mono- and
Dimethoxy Acetaldehyde,
Org. Lett. 2003, 5, 2047–2050.
43. Murillo Villela Filho, Thomas Stillger, Michael Müller, Andreas Liese, Christian Wandrey,
Is log P a Convenient Criterion to Guide the Choice of Solvents for Biphasic Enzymatic Reactions?,
Angew. Chem. 2003, 115, 3101–3104; Angew. Chem. Int. Ed. 2003, 42, 2993–2996.
44. Bettina Lingen, Doris Kolter, Pascal Dünkelmann, Ralf Feldmann, Joachim Grötzinger, Martina Pohl,
Michael Müller,
Alteration of the Substrate Specificity of Benzoylformate Decarboxylase from Ps. putida by Directed
Evolution,
ChemBioChem 2003, 4, 721–726.
45. Dirk Franke, Georg A. Sprenger, Michael Müller,
Easy access to monofunctionalized trans-3,4-dihydroxycyclohexa-1,5-diens with engineered strains of
Escherichia coli,
ChemBioChem 2003, 4, 775–777.
46. Dirk Franke, Volker Lorbach, Simon Esser, Christian Dose, Georg A. Sprenger, Markus Halfar, Jörg
Thömmes, Rolf Müller, Ralf Takors, Michael Müller,
(S,S)-2,3-Dihydroxy-2,3-dihydrobenzoic Acid: Microbial Access with Engineered Cells of Escherichia
coli and Applicability as Starting Material in Natural Product Synthesis,
Chem. Eur. J. 2003, 9, 4188–4196.
47. Wolfgang Hüttel, Martin Nieger, Michael Müller,
A Short and Efficient Total Synthesis Synthesis of the Naturally Occuring Coumarins Siderin, Kotanin,
Isokotanin A and Desertorin C,
Synthesis 2003, 1803–1808.
48. Georg A. Sprenger, Marcel Wubbolts, Johannes Bongaerts, Michael Müller, Stefan Kozak, R
Bovenberg,
Biosynthetic production of 4-amino-4-deoxychorismate (ADC) and [3R,4R]-4-amino-3hydroxycyclohexa-1,5-diene-1-carboxylic ACID (3,4-CHA.)
EP04076644.6, PCT/EP2005/005988, eingereicht 04.06.2004.
49. Michael Müller,
Highlights 2003: Enzyme in der organischen Synthese,
Nachr. Chem. 2004, 52, 287–288.
50. Wolfgang Hüttel, Michael Müller,
Buchrezension: Pocket Guide Biotechnology, by Rolf D. Schmid,
Nachr. Chem. 2004, 52, 833–835.
51. Pascal Dünkelmann, Martina Pohl, Michael Müller,
Enantiomerically pure 2-hydroxy carbonyl compounds through enzymatic C-C bond formation,
Chemistry Today 2004, 24–28.
52. Volker Lorbach, Dirk Franke, Simon Esser, Christian Dose, Georg A. Sprenger, Michael Müller,
Microbially produced functionalized cyclohexadiene-trans-diols as a new class of chiral building blocks
in organic synthesis: on the way to green and combinatorial chemistry,
in Bioorganic Chemistry II, VCH-Wiley, 2004, 511–523.
53. Volker Lorbach, Dirk Franke, Georg A. Sprenger, Michael Müller,
Metabolic pathway engineering,
in Bioorganic Chemistry II, VCH-Wiley, 2004, 524–525.
54. Bettina Lingen, Martina Pohl, Ayhan S. Demir, Andreas Liese, Michael Müller,
Enantioselective Synthesis of Hydroxy Ketones via Benzoylformate Decarboylase- and Benzaldehyde
Lyase-catalyzed C-C Bond Formation,
in Thiamine: Catalytic Mechanisms and Role in Normal and Disease States,
Marcel Dekker, New York, 2004, 113–129.
55. Michael Müller, Georg A. Sprenger,
Thiamine-dependent enzymes as catalysts of C-C-bonding reactions: The role of “orphan” enzymes,
in Thiamine: Catalytic Mechanisms and Role in Normal and Disease States,
Marcel Dekker, New York, 2004, 77–91.
56. Michael Müller, Kai Lamottke, Wolfgang Steglich, Steffan Busemann, Matthias Reichert, Gerhard
Bringmann, Peter Spiteller,
Biosynthesis and Stereochemistry of Phlegmacin-Type Fungal Pigments ,
Eur. J. Org. Chem. 2004, 4850–4855.
57. Dieter Enders, Achim Lenzen, Michael Müller,
Efficient Asymmetric Syntheses of (+)-Strictifolione,
Synthesis 2004, 1486–1488.
58. Martina Pohl, Georg A. Sprenger, Michael Müller
A new perspective on thiamine catalysis,
Current Opinion Biotechnol. 2004, 15, 335–342.
59. Michael Wolberg, Iwona A. Kaluzna, Michael Müller, Jon D. Stewart,
Regio and enantioselective reduction of t-butyl 6-chloro-3,5-dioxohexanoate with baker’s yeast
Tetrahedron: Asymmetry 2004, 15, 2825–2828.
60. Michael Müller
Chemical diversity through biotransformations,
Current Opinion Biotechnol. 2004, 15, 591–598.
61. Johannes Bongaerts, Leon Raeven, Michael Müller, Volker Lorbach,
Biosynthetic production of 2-amino-2-deoxyisochorismate (ADIC) and [5R,6S]-6-amino-5hydroxycyclohexa-1,3-diene-1-carboxylic ACID (2,3-CHA) (WO 2006/128706)).
62. Michael Müller,
Highlights 2004: Enzyme in der organischen Synthese,
Nachr. Chem. 2005, 53, 270.
63. Michael Müller, Michael Wolberg, Thomas Schubert, Werner Hummel,
Enzyme-catalyzed regio- and enantioselective ketone reductions,
in Advances in Biochemical Engineering/Biotechnology, Volume Title: Technology Transfer in
Biotechnology: From Lab to Industry to Production, Springer Verlag, Heidelberg 2005, 92, 261–287.
64. Michael Müller,
Chemoenzymatic synthesis of statin side-chain building blocks,
Angew. Chem. 2005, 117, 366–369; Angew. Chem. Int. Ed. 2005, 44, 362–365.
65. Marianne Ernst, Björn Kaup, Michael Müller, Stephanie Bringer-Meyer, Hermann Sahm,
Enantioselective reduction of carbonyl-compounds by whole-cell biotransformation, combining a
formate dehydrogenase and a (R)-specific alcohol dehydrogenase,
Appl. Microbiol. Biotechnol. 2005, 66, 629–634.
66. Tanja G. Mosbacher, Michael Müller, Georg E. Schulz
Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas
fluorescens,
FEBS Journal 2005, 272, 6067–6076.
67. Philippe Bisel, Michael Müller,
Highlights 2005: Enzyme in der organischen Synthese,
Nachr. Chem. 2006, 54, 258.
68. Silke Bode, Michael Wolberg, Michael Müller,
Stereoselective Synthesis of 1,3-Diols,
Synthesis 2006, 557–588.
69. Jean Detry, Thorsten Rosenbaum, Stephan Lütz, Doris Hahn, Karl-Erich Jaeger, Michael Müller,
Thorsten Eggert,
Biocatalytic production of enantiopure cyclohexane-trans-1,2-diol using extracellular lipases from
Bacillus subtilis,
Appl. Microbiol. Biotechnol. 2006, 72, 1107–1116.
70. C. Bihlmaier, E. Welle, C. Hofmann, K. Welzel, A. Vente, E. Breitling, M. Müller, S. Glaser, A. Bechthold,
Biosynthetic Gene Cluster for the Polyenoyltetramic Acid α-Lipomycin,
Antimicrobiol. Agents Chemother. 2006, 50, 2113–2121.
71. Elena Janzen, Michael Müller, Doris Kolter-Jung, Malea M. Kneen, Michael J. McLeish, Martina Pohl,
Characterization of benzaldehyde lyase from Pseudomonas fluorescens: A versatile enzyme for
asymmetric C-C bond formation,
Bioorg. Chem. 2006, 34, 345–361.
72. Helge Henning, Christian Leggewie, Martina Pohl, Michael Müller, Thorsten Eggert, Karl-Erich Jäger,
Identification of novel benzyolformate decarboxylases by growth selection,
Appl. Environ. Micobiol. 2006, 72, 7510–7517.
73. Michael Knoll, Michael Müller, Jürgen Pleiss, Martina Pohl,
Factors mediating Activity, Selectivity, and Substrate Specificity for the Thiamin DiphosphateDependent Enzymes Benzaldehyde Lyase and Benzoylformate Decarboxylase,
ChemBioChem 2006, 7, 1928–1934.
74. Michael Müller, Marcel Wubbolts,
Biotransformation Methods for Preparing Chiral Drugs and Drug Intermediates, in
Chirality in Drug Research, Methods and Principles in Medicinal Chemistry, Volume 33, (Eds. E.
Francotte, W. Lindner) Wiley-VCH, Weinheim, 2006, 95–123.
75. Marion Wendorff, Thorsten Eggert, Martina Pohl, Carola Dresen, Michael Müller, Karl-Erich Jaeger,
Directed Evolution to Increase the Substrate Range of Benzoylformate Decarboxylase from
Pseudomonas putida,
in Asymmetric Synthesis with Chemical and Biological Methods, Wiley-VCH, Weinheim, 2007, 298–311.
76. Andrea Weckbecker, Michael Müller, Werner Hummel,
Preparative Syntheses of Chiral Alcohols using (R)-Specific Alcohol Dehydrogenases from Lactobacillus
Strains,
in Asymmetric Synthesis with Chemical and Biological Methods, Wiley-VCH, Weinheim, 2007, 341–350.
77. Michael Müller, Michael Wolberg, Silke E. Bode, Ralf Feldmann, Petra Geilenkirchen, Thomas
Schubert, Lydia Walter, Werner Hummel, Thomas Dünnwald, Ayhan S. Demir, Doris Kolter-Jung,
Adam Nitsche, Pascal Dünkelmann, Annabel Cosp, Martina Pohl, Bettina Lingen, Maria-Regina Kula,
Flexible asymmetric redoxreactions and C-C bond formations by bioorganic synthetic strategies, in
Asymmetric Synthesis with Chemical and Biological Methods, Wiley-VCH, Weinheim, 2007, 386–413.
78. Philippe Bisel, Michael Müller,
Highlights 2006: Enzyme in der organischen Synthese,
Nachr. Chem. 2007, 55, 271–272.
79. Falk Hildebrand, Sven Kühl, Martina Pohl, Durda Vasic-Racki, Michael Müller, Christian Wandrey,
Stephan Lütz,
The production of (R)-2-hydroxy-1-phenyl-propan-1-one derivatives by benzaldehyde lyase from
Pseudomonas fluorescens in a continuously operated membrane reactor,
Biotechnol. Bioengineering 2007, 96, 835–843.
80. Wolfgang Hüttel, Michael Müller,
Regio- and Stereoselective intermolecular oxidative phenol coupling in kotanin biosynthesis by
Aspergillus niger,
ChemBioChem 2007, 8, 521–529.
81. Daniel Drochner, Wolfgang Hüttel, Silke E. Bode, Michael Müller, Ulrich Karl, Martin Nieger, Wolfgang
Steglich, Dimeric Orsellinic Acid Derivatives: Valuable Intermediates for Natural Product Synthesis,
Eur. J. Org. Chem. 2007, 1749–1758.
82. Yin-Ru Chiang, Wael Ismail, Michael Müller, Georg Fuchs,
Initial steps in the anoxic metabolism of cholesterol by the denitrifying Sterolibacterium denitrificans,
J. Biol. Chem. 2007, 282, 13240–13249.
83. Pablo Domínguez de María, Martina Pohl, Dörte Gocke, Harald Gröger, Harald Trauthwein, Thomas
Stillger, Lydia Walter, Michael Müller,
Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes,
Eur. J. Org. Chem. 2007, 2940–2944.
84. Dörte Gocke, Con Luan Nguyen, Martina Pohl, Thomas Stillger, Lydia Walter, Michael Müller,
Branched-chain ketoacid decarboxylase from Lactococcus lactis (KdcA), a new thiamin diphosphatedependent enzyme for asymmetric C-C bond formation,
Adv. Synth. Catal. 2007, 349, 1425–1435.
85. Philippe Bisel, Lydia Walter, Martin Nieger, Michael Müller,
Stereochemical clarification of the enzyme-catalysed reduction of 2-acetylchromen-4-one,
Tetrahedron: Asymmetry 2007, 18, 1142–1144.
86. Tobias J. Erb, Ivan A. Berg, Volker Brecht, Michael Müller, Georg Fuchs, Birgit E. Alber,
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The
ethylmalonyl-CoA pathway,
PNAS 2007, 104, 10631–10636.
87. Silke E. Bode, Daniel Drochner, Michael Müller,
Synthesis, Biosynthesis and absolute Configuration of Vioxanthin,
Angew. Chem. 2007, 119, 6020–6024; Angew. Chem. Int. Ed. 2007, 46, 5916–5920.
88. Sven Kühl, Daniela Zehentgruber, Martina Pohl, Michael Müller, Stephen Lütz
Process development for enzmye catalysed asymmetric C-C bond formation
Chemical Engineering Science 2007, 62, 5201–5205.
89. Carola Dresen, Michael Richter, Michael Müller,
Verwendung de PigD-Proteins zur Katalyse von 1,4-Additionen von 2-Oxoalkanoaten an alpha-, betaungesättigte Ketone, DE 102007021698.1, 09.05.2007.
90. Christoph Krekel, Stella Eichner, Karin Geißinger, Michael Müller,
Efeulacca - Bericht von einem vergessenen Farbmittel,
Zeitschrift für Kunsttechnologie und Konservierung 2007, 21, 287–296.
91. Philippe Bisel, Michael Müller,
Highlights 2007: Enzymreaktionen,
Nachr. Chem. 2008, 56, 278–279.
92. Dörte Gocke, Lydia Walter, Ekaterina Gauchenova, Geraldine Kolter, Michael Knoll, Catrine L.
Berthold, Gunter Schneider, Jürgen Pleiss, Michael Müller, Martina Pohl,
Rational Protein Design of ThDP-Dependent Enzymes - Engineering Stereoselectivity,
ChemBioChem 2008, 9, 406–412.
93. Jan Zarzycki, Ansgar Schlichting, Nina Strychalski, Michael Müller, Birgit E. Alber, Georg Fuchs,
Mesaconyl-Coenzyme A Hydratase, a New Enzyme of Two Central Carbon Metabolic Pathways in
Bacteria,
J. Bacteriol. 2008, 190, 1366–1374.
94. Anabel Cosp, Carola Dresen, Martina Pohl, Lydia Walter, Caroline Röhr, Michael Müller
α,β-Unsaturated aldehydes as substrates for asymmetric C-C bond forming reactions with thiamine
diphosphate (ThDP)-dependent enzymes,
Adv. Synth. Catal. 2008, 350, 759–771.
95. Michael Wolberg, Murillo Villela Filho, Silke Bode, Petra Geilenkirchen, Ralf Feldmann, Andreas
Liese, Werner Hummel, Michael Müller,
Chemoenzymatic synthesis of the chiral side-chain of statins: application of an alcohol
dehydrogenase-catalysed ketone reduction on a large scale,
Bioprocess Biosyst. Eng. 2008, 31, 183–191.
96. Philippe Bisel, Loay Al-Momani, Michael Müller,
The tert-butyl group in Chemistry and Biology,
Organic Biomol. Chem. 2008, 6, 2655–2665.
97. Bärbel Thiele, Oliver Rieder, Nico Jehmlich, Martin von Bergen, Michael Müller, Matthias Boll,
Aromatizing Cyclohex-1,5-diene-1-carbonyl-Coenzyme A Oxidase: Characterization and its Role in
Anaerobic Aromatic Metabolism,
J. Biol. Chem. 2008, 283, 20713–20721.
98. Alexander Pontius, Anja Krick, Stefan Kehraus, Silke E. Foegen, Michael Müller, Karin Klimo, Clarissa
Gerhäuser, Gabriele M. König,
Noduliprevenone, a novel heterodimeric chromanone with cancer chemopreventive potential
Chem. Eur. J. 2008, 14, 9860–9863.
99. Alexander Pontius, Anja Krick, Ronak Mesry, Stefan Kehraus, Silke E. Foegen, Michael Müller, Karin
Klimo, Clarissa Gerhäuser, Gabriele M. König,
Monodictyochrome A and B, Dimeric Xanthone Derivatives from the Marine Algicolous Fungus
Monodictys putredinis,
J. Nat. Prod. 2008, 71, 1793–1799.
100. Bärbel Thiele, Oliver Rieder, Bernard Golding, Michael Müller, Matthias Boll,
Mechanism of Enzymatic Birch Reduction: Stereochemical Course and Exchange Reactions of
Benzoyl-CoA Reductase,
J. Am. Chem. Soc. 2008, 130, 14050–14051.
101. Martina Pohl, Dörte Gocke, Michael Müller,
Thiamin-based Enzymes for Biotransformations,
in Green Chemistry, Anastas PT, editor. Handbook of Green Chemistry, Green Catalysis, Vol. 3
Biocatalysis. Weinheim: Wiley-VCH. 2008, p 75–114.
102. Patrizia Lehwald, Michael Richter, Michael Müller,
Verfahren zur stereospezifischen Synthese von Verbindungen mit einem Enzym aus Yersinia, EP
08009054.1, 16.05.2008.
103. Steffen Lüdeke, Michael Richter, Michael Müller,
Stereoselective synthesis of three isomers of tert-butyl 5-hydroxy-4-methyl-3-oxohexanoate through
alcohol dehydrogenase-catalyzed dynamic kinetic resolution,
Adv. Synth. Catal. 2009, 351, 253–259.
104. Volker Auwärter, Sebastian Dresen, Wolfgang Weinmann, Michael Müller, Michael Pütz, Nerea Ferreirós
Spice and other herbal blends: harmless incense or cannabinoid designer drugs?,
Journal of Mass Spectrometry 2009, 44, 832–837.
105. Wolfgang Hüttel, Michael Müller
Highlights 2008: Enzyme in der organischen Synthese,
Nachr. Chem. 2009, 57, 274–275.
106. Dörte Gocke, Thorsten Graf, Helen Brosi, Ilona Frindi-Wosch, Lydia Walter, Michael Müller, Martina
Pohl,
Comparative characterisation of thiamin diphosphate-dependent decarboxylases,
J. Mol. Catal., B: Enzym. 2009, 61, 30–35.
107. Anja Kurutsch, Michael Richter, Volker Brecht, Georg A. Sprenger, Michael Müller,
MenD as a versatile catalyst for asymmetric synthesis,
J. Mol. Catal., B: Enzym. 2009 61, 56–66.
108. Andreas Liese, Michael Müller, Martina Pohl, Dieter Sell, Kai Tittmann,
Special Issue: Chemical Biology of Thiamine (Editorial),
J. Mol. Catal., B: Enzym. 2009, 61, 1.
109. Michael Müller, Dörte Gocke, Martina Pohl,
Exploitation of ThDP-dependent enzymes for asymmetric chemoenzymatic synthesis,
FEBS Journal 2009 276, 2894–2904.
110. Tobias J. Erb, Volker Brecht, Michael Müller, Georg Fuchs, Birgit E. Alber,
Carboxylation mechanism and stereochemistry of crotonyl.CoA carboxylase/reductase, a
carboxylating enoyl-thioester reductase,
PNAS 2009, 106, 8877–8882.
111. Michael Müller, Christian Klein,
Bookreview: Practical Biotransformations. A Beginner's Guide. von Gideon Grogan.
Angewandte Chemie. 2009, 121, 8321-8322; Angewandte Chemie Int. Ed. 2009, 48, 8175–8176.
112. Jan Zarzycki, Volker Brecht, Michael Müller, Georg Fuchs,
Final steps of an autotrophic pathway: closing the 3-hydroxypropionate bicycle in Chloroflexus
aurantiacus,
PNAS 2009, 106, 21317–21322.
113. Patrizia Lehwald, Michael Richter, Caroline Röhr, Hung-wen Liu, Michael Müller,
Enantioselective Intermolecular Aldehyde-Ketone Cross-Coupling through an Enzymatic Carboligation
Reaction,
Angew. Chem. 2010, 122, 2439–2442; Angew. Chem. Int. Ed. 2010, 49, 2389–2392.
114. Dörte Gocke, Geraldine Kolter, Michael Müller, Martina Pohl
Entwicklung einer Enzymplattform für die biokatalytische C-C-Verknüpfung
Chemie Ingenieur Technik 2010, 82, 81–86.
115. Wolfgang Hüttel, Michael Müller,
Highlights 2009: Enzyme in der organischen Synthese,
Nachr. Chem. 2010, 58, 288–290.
116. Martina Daum, Hans-Jörg Schnell, Simone Herrmann, Andreas Günther, Renato Murillo, Rolf Müller,
Philippe Bisel, Michael Müller, Andreas Bechthold,
Functions of Genes and Enzymes Involved in Phenalinolactone Biosynthesis,
ChemBioChem 2010, 11, 1383–1391.
117. Carola Dresen, Michael Richter, Martina Pohl, Steffen Lüdeke, Michael Müller,
The Enzymatic Asymmetric Conjugate Umpolung Reaction,
Angew. Chem. 2010, 122, 6750–6753; Angew. Chem. Int. Ed. 2010, 49, 6600–6603.
118. Johannes W. Kung, Sven Baumann, Martin von Bergen, Michael Müller, Peter-Leon Hagedoorn,
Wilfred R. Hagen, Matthias Boll,
Reversible Biological Birch Reduction at an Extremely Low Redox Potential,
J. Am. Chem. Soc. 2010, 132, 9850–9856.
119. Wolfgang Hüttel, Michael Müller,
Highlights 2010: Enzyme in der organischen Synthese,
Nachr. Chem. 2011, 59, 282–283.
120. Danilo Meyer, Lydia Walter, Geraldine Kolter, Martina Pohl, Michael Müller, Kai Tittmann,
Conversion of Pyruvate Decarboxylase into an Enantioselective Carboligase with Biosynthetic Potential,
J. Am. Chem. Soc. 2011, 133, 3609–3616.
121. Dörte Rother, Geraldine Kolter, Tina Gerhards, Catrine L. Berthold, Ekaterina Gauchenova, Michael
Knoll, Jürgen Pleiss, Michael Müller, Gunter Schneider, Martina Pohl,
S-selective mixed carboligation by structure-based design of the pyruvate decarboxylase from
Acetobacter pasteurianus,
ChemCatChem 2011, 3, 1587–1596.
122. Syed Masood Husain, Thomas Stillger, Pascal Dünkelmann, Melanie Lödige, Lydia Walter, Elke
Breitling, Martina Pohl, Mara Bürchner, Ingo Krossing, Michael Müller, Diego Romano, Francesco
Molinari,
Stereoselective Reduction of 2-Hydroxy Ketones towards syn- and anti-1,2-Diols,
Adv. Synth. Catal. 2011, 353, 2359–2362.
123. Johannes Bongaerts, Simon Esser, Volker Lorbach, Lóay Al-Momani, Michael A. Müller, Dirk Franke,
Christoph Grondal, Anja Kurutsch, Robert Bujnicki, Ralf Takors, Leon Raeven, Marcel Wubbolts, Roel
Bovenberg, Martin Nieger, Melanie Schürmann, Natalie Trachtmann, Stefan Kozak, Georg A.
Sprenger, Michael Müller,
Diversity-oriented production of metabolites derived from chorismate and their use in organic
synthesis, Angew. Chem. 2011, 123, 7927–7932; Angew. Chem. Int. Ed. 2011, 50, 7781–7786.
124. Pascal Dünkelmann, Michael Müller,
Enzymatic C-C coupling in the synthesis of fine chemcials,
Speciality Chemicals Magazine 2011, 31, 16–18.
125. Regine Süss, Rolf Schubert, Irmgard Merfort, Michael Müller, Andreas Bechthold, Manfred Jung,
Martin Müller, Rüdiger Holzbach, Ernst Pallenbach,
Arzneimittelabhängigkeit und Suchtkrankheiten – ein Beitrag der Klinischen Pharmazie
Pharm. Ztg. 2011, 156, 72–74.
126. Michael Müller,
Diversität asymmetrischer Thiamin-Katalyse,
Biospektrum 2011, 17, 281–283;
und in Biochemie und molekulare Biologie – Das Beste aus BIOspektrum, Ed. J. Alves, Springer
Spektrum, 2012.
127. Michael A. Schätzle, Stephan Flemming, Syed Masood Husain, Michael Richter, Stefan Günther,
Michael Müller,
Tetrahydroxynaphthalene Reductase – Catalytic Properties of an Enzyme Involved in Reductive
Asymmetric Naphthol Dearomatization,
Angew. Chem. 2012, 124, 2697–2700; Angew. Chem. Int. Ed. 2012, 51, 2643–2466.
128. Stefan Kneisel, Philippe Bisel, Volker Brecht, Sebastian Broecker, Michael Müller, Volker Auwärter,
Identification of the cannabimimetic AM-1220 and its azepane isomer (N-methylazepan-3-yl)-3-(1naphthoyl)indole in a research chemical and several herbal mixtures,
Forensic Toxicol. 2012, 30, 126–134.
129. Syed Masood Husain, Michael A. Schätzle, Caroline Röhr, Steffen Lüdeke, Michael Müller,
Biomimetic asymmetric synthesis of (R)-GTRI-02 and (3S,4R)-3,4-dihydroxy-3,4-dihydronaphthalen1(2H)-ones,
Org. Lett. 2012, 14, 3600–3603.
130. Christian Gil Girol, Katja M. Fisch, Thorsten Heinekamp, Stefan Günther, Wolfgang Hüttel, Jörn Piel,
Axel A. Brakhage, Michael Müller,
Regio- and Stereoselective Oxidative Phenol Coupling in Aspergillus niger,
Angew. Chem. 2012, 124, 9926–9929; Angew. Chem. Int. Ed. 2012, 51, 9788–9791.
131. Martina Pohl, Carola Dresen, Maryam Beigi, Michael Müller,
Enzymatic Acyloin and Benzoin Condensations,
in Enzyme Catalysis in Organic Synthesis, Third Edition. Edited by Karlheinz Drauz, Harald Gröger,
and Oliver May: Wiley-VCH, Weinheim, 2012 chapter 22, 919–945.
132. Jennifer Andexer, Michael Müller,
Highlights 2011: Enzymreaktionen,
Nachr. Chem. 2012, 60, 294–295.
133. Christian Gil Girol, Wolfgang Hüttel, Silke Fögen, Katja M. Fisch, Jörn Piel, Thorsten Heinekamp, Axel
Brakhage, Michael Müller,
Regio- and stereoselektive intermolecular oxidative phenol coupling in filamentous fungi,
Pharmaceutical Biology 2012, 50, 617.
134. Michael A. Schätzle, Syed Masood Husain, Sascha Ferlaino, Michael Müller,
Enzymatic reduction of anthrahydoquinones: implications für chrysophanol, monodictyphenone and
related xanthone biosyntheses,
J. Am. Chem. Soc. 2012, 134, 14742–14745.
135. Nadine Roth, Ariane Wohlfarth, Michael Müller, Volker Auwärter,
Regioselective synthesis of isotopically labeled 9-tetrahydrocannabinolic acid A (THCA-A-D3) by
reaction of 9-tetrahydrocannabinol-D3 with magnesium methyl carbonate,
Forensic Sci. Int. 2012, 222, 368–372.
136. Michael Müller,
Recent Developments in Enzymatic Asymmetric C-C Bond Formation,
Adv. Synth. Catal. 2012, 354, 3161–3174.
137. Maryam Beigi, Sabrina Loschonsky, Patrizia Lehwald, Volker Brecht, Susana L. A. Andrade, Finian J.
Leeper, Werner Hummel, Michael Müller,
α-Hydroxy--keto Acid Rearrangement–Decarboxylation: Impact on ThDP-Dependent Enzymatic
Transformations,
Org. Biomol. Chem. 2013, 11, 252–256.
138. Maryam Beigi, Simon Waltzer, Alexander Fries, Lothar Eggeling, Georg A. Sprenger, Michael Müller,
TCA Cycle Involved Enzymes SucA and Kgd, as well as MenD: Efficient Biocatalysts for Asymmetric
C–C Bond Formation,
Org. Lett. 2013, 15, 452–455.
139. Robert Westphal, Simon Waltzer, Ursula Mackfeld, Michael Widmann, Jürgen Pleiss, Maryam Beigi,
Michael Müller, Dörte Rother, Martina Pohl,
(S)-Selective MenD variants from Escherichia coli provide access to new functionalized chiral αhydroxy ketones,
Chem. Commun. 2013, 49, 2061–2063.
140. Jennifer Andexer, Michael Müller,
Highlights 2012: Enzymreaktionen,
Nachr. Chem. 2013, 61, 286–288.
141. Michael Müller, Georg A. Sprenger, Martina Pohl,
C–C Bond Formation Using ThDP-Dependent Lyases,
Current Opinion Chem. Biol. 2013, 17, 261–270.
142. Michael Müller,
Biokatalytische Synthese tertiärer Alkohole,
Chemie Ingenieur Technik 2013, 85, 795–808.
143. Matthias Häckh, Michael Müller, Steffen Lüdeke,
Substrate-Dependent Stereospecificity of Tyl-KR1, an Isolated Polyketide Synthase Ketoreductase
Domain from Streptomyces fradiae,
Chem. Eur. J. 2013, 19, 8922–8928.
144. Christian Eberlein, Sebastian Estelmann, Jana Seifert, Martin von Bergen, Michael Müller, Rainer U.
Meckenstock, Matthias Boll,
Identification and characterization of 2-naphthoyl-coenzyme A reductase, the prototype of a novel
class of dearomatizing reductases,
Mol. Microbiol. 2013, 88, 1032–1039.
145. Robert Westphal, Doris Hahn, Ursula Mackfeld, Simon Waltzer, Maryam Beigi, Michael Müller,
Michael Widmann, Constatin Vogel, Jürgen Pleiss, Dörte Rother, Martina Pohl,
Tailoring (S)-selectivity of MenD from Escherichia coli,
ChemCatChem 2013, 5, 3587–3594.
146. Helen Hailes, Dörte Rother, Michael Müller, Robert Westphal, John Ward, Jürgen Pleiss, Constantin
Vogel, Martina Pohl,
Engineering Stereoselectivity of ThDP-dependent Enzymes,
FEBS Journal 2013, 280, 6374–6394.
147. Robert Westphal, Sascha Jansen, Constantin Vogel, Jürgen Pleiss, Michael Müller, Dörte Rother,
Martina Pohl,
MenD from Bacillus subtilis: A Potent Catalyst for the Enantiocomplementary Asymmetric Synthesis of
Functionalized α-Hydroxy Ketones,
ChemCatChem 2014, 6, 1082–1088.
148. Sabrina Loschonsky, Simon Waltzer, Sonja Fraas, Peter M. H. Kroneck, Tobias Wacker, Susana L. A.
Andrade, Michael Müller,
Catalytic Scope of Thiamine-Dependent Multifunctional Enzyme Cyclohexane-1,2-dione Hydrolase,
ChemBioChem 2014, 15, 389–392.
149. Sabrina Loschonsky, Simon Waltzer, Michael Müller,
Elucidation of the Enantioselective Cyclohexane-1,2-dione Hydrolase (CDH) Catalyzed Formation of
(S)-Acetoin,
ChemCatChem 2014, 6, 969–972.
150. Michael Müller,
Entzymatic synthesis of tertiary alcohols,
ChemBioEng Reviews 2014, 1, 14–26.
151. Petra Mußler, Michael Müller,
Pharmazie quo vadis,
Das Hochschulwesen 2014, (1+2), 64–68.
152. Andreas Präg, Björn Andreas Grüning, Anika Erxleben, Matthias Häckh, Steffen Lüdeke, Andriy
Luzhetskyy, Michael Richter, Marta Luzhetska, Stefan Günther, Michael Müller,
Regio- and Stereoselective Intermolecular Oxidative Phenol Coupling in Streptomyces,
J. Am. Chem. Soc. 2014, 136, 6195–6198.
153. Tobias Huber, Lisa Schneider, Andreas Präg, Stefan Gerhardt, Oliver Einsle, Michael Müller,
Direct Reductive Amination of Ketones: Structure and Activity of (S)-Selective Imine Reductases from
Streptomyces,
ChemCatChem 2014, 6, 2248–2252.
154. Robert Westphal, Constantin Vogel, Carlo Schmitz, Jürgen Pleiss, Michael Müller, Martina Pohl, Dörte
Rother,
Tailor-made Pyruvate Decarboxylase for the Direct Asymmetric Synthesis of (S)-Benzoins,
Angew. Chem. 2014, 126, 9530–9533; Angew. Chem. Int. Ed. 2014, 53, 9376–9379.
155. Syed Masood Husain, Michael A. Schätzle, Steffen Lüdeke, Michael Müller,
Unprecedented role of hydronaphthoquinone tautomers in biosynthesis,
Angew. Chem. 2014, 126, 9964–9969; Angew. Chem. Int. Ed. 2014, 53, 9806–9811.
156. Elena Kasparyan, Michael Richter, Carola Dresen, Lydia S. Walter, Georg Fuchs, Finian J. Leeper,
Tobias Wacker, Susana L. A. Andrade, Geraldine Kolter, Martina Pohl, Michael Müller,
Asymmetric Stetter Reactions Catalyzed by Thiamine Diphosphate-Dependent Enzymes,
Appl. Microbiol. Biotechnol. 2014, 98, 9681–9690.
157. Maryam Beigi, Simon Waltzer, Mostafa Zarfei, Michael Müller,
New Stetter reactions catalyzed by Thiamine Diühosphate dependent MenD from E.coli,
Journal of Biotechnology 2014, 191, 64–68.
158. Florian Hubrich, Michael Müller, Jennifer N. Andexer,
In vitro production and purification of isochorismate using a two-enzyme cascade,
Journal of Biotechnology 2014, 191, 93–98.
159. Sabrina Loschonsky, Tobias Wacker, Simon Waltzer, Pier Paolo Giovannini, Michael J. McLeish,
Susana L. A. Andrade, Michael Müller,
Extended Reaction Scope of Thiamine Diphosphate Dependent Cyclohexane-1,2-dione Hydrolase:
From C–C Bond Cleavage to C–C Bond Ligation,
Angew. Chem. 2014, 126, 14630–14634; Angew. Chem. Int. Ed. 2014, 53, 14402–14406.
160. Martina Pohl, Cindy Wechsler, Michael Müller,
Acyloin, Benzoin, and Related Reactions, in Science of Synthesis, Biocatalysis in Organic Synthesis 2
(Eds. K. Faber, W.-D. Fessner, N. J. Turner), Thieme, 2015, 93–131.
161. Giovanni Bernacchia, Olga Bortolini, Morena De Bastiani, Lindomar Alberto Lerin, Sabrina
Loschonsky, Alessandro Massi, Michael Müller, Pier Paolo Giovannini,
Enzymatic Chemoselective Aldehyde–Ketone Cross-Couplings through the Polarity Reversal of
Methylacetoin,
Angew. Chem. 2015, 127, 7277–7281; Angew. Chem. Int. Ed. 2015, 54, 7171–7175.
162. Dennis Wetzl, Marco Berrera, Nicolas Sandon, Dan Fishlock, Martin Ebeling, Michael Müller, Steven
Paul Hanlon, Beat Wirz, Hans Iding,
Expanding the imine reductase toolbox by exploring the bacterial protein sequence space,
ChemBioChem 2015, 16, in press (DOI: 10.1002/cbic.201500218).
163. Stefanie Houwaart, Dominik Baltes, Jonas Pavelka, Michael Müller,
Forschungsethik –Verantwortung des Naturwissenschaftlers im interdisziplinären Dialog,
Buchbeitrag Klausurwoche Greifswald (in press).
164. Carola Dresen, Elena Kasparyan, Lydia S. Walter, Fabrizio Bonina, Simon Waltzer, Michael Müller,
Stetter Reactions Catalyzed by Thiamine Diphosphate-Dependent Enzymes,
Kroutil, Buchbeitrag (in press).
165. Michael A. Schätzle, Syed Masood Husain, Michael Müller,
Tetrahydroxynaphthalene Reductase – Catalytic Properties of an Enzyme Involved in Reductive
Asymmetric Naphthol Dearomatization,
Kroutil, Buchbeitrag (in press).
166. David Conradt, Michael A. Schätzle, Syed Masood Husain, Michael Müller,
Diversity in Reduction with Short Chain Dehydrogenases (T 4HNR, T3HNR, GDH),
ChemCatChem 2015, 7, in press (DOI: 10.1002/cctc.201500605).