Die Fakultät für Chemie

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Die Fakultät für Chemie
und die
Gesellschaft Deutscher Chemiker
gemeinsam mit
SFB 613: Physik von Einzelmolekülprozessen und
molekularer Erkennung in organischen Systemen
International Graduate School of Chemistry and
Biochemistry
laden ein zum Vortrag von
Prof. Dr. Burkhard König
Universität Regensburg
“Molecular Recognition with Metal
Complexes and Heterocycles”
Selective recognition of peptides under physiological conditions, specific binding of
a protein surface or guided self-assembly of molecules on surfaces are challenging
tasks in supramolecular chemistry. Synthetic receptors that can achieve such tasks
are interesting as diagnostic tools in medicinal chemistry and molecular biology,
due to their higher stability and simpler functionalization compared to antibodies.
The lecture presents our recent examples of metal complex based luminescent
synthetic receptors, organic peptide mimics and guided self-assembly at interfaces.
Their properties are compared with related systems from literature.
selective
coordination O
H
N
and intramolecular R
binding
O
O
O
O
O
O
H
O
O
N
O
O
Cu
N
N
i+3 N
O
O
O
O + O
O O
NH3
N
N
O
H
O
yield emission
signal
Luminescent dipeptide receptor
i+3
N
O H
Oi
H
N
Br
iO
H
N
H
Heterocyclic peptide mimic
References:
S. Stadlbauer, A. Riechers, A. Späth, B. König, Chem.
Eur. J., 2008, DOI: 10.1002/chem.200701442:
Utilizing Reversible Copper(II) Peptide Coordination
in a Sequence Selective Luminescent Receptor
M. Kruppa, B. König, Chem. Rev. 2006, 106, 3520 –
3560: Reversible Coordinative Bonds in Molecular
Recognition
M. Kruppa, C. Mandl, S. Miltschitzky, B. König, J. Am.
Chem. Soc. 2005, 127, 3362 – 3365: A Luminescent
Receptor with Affinity for N-terminal Histidine in
Peptides in Aqueous Solution
P. Maity, M. Zabel, B. König, J. Org. Chem. 2007, 72,
8046 – 8053: Tetrahydrofuran Cα-Tetrasubstituted
Amino Acids: Two Consecutive β Turns in a
Crystalline Linear Tripeptide
Guided self-assembly at
interfaces
D. S. Turygin, M. Subat, O. A. Raitman, V. V.
Arslanov, B. König, M. A. Kalinina, Angew. Chem. Int.
Ed. 2006, 45, 5340 – 5344: Cooperative SelfAssembly of Adenosine and Uridine Nucleotides on
2-D Synthetic Template
Universitätsgebäude, Hörsaal 3
Donnerstag, den 26. Juni 2008 um 17 Uhr c.t.
Gez. Prof. Dr. Thomas Koop, Prof. Dr. Uwe Manthe, Prof. Dr. Jochen
Mattay
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